my results are in (they faxed me them here), seeing doctor next week – ….. Methylation

Home The Candida Forum Candida Questions my results are in (they faxed me them here), seeing doctor next week – ….. Methylation

This topic contains 5 replies, has 2 voices, and was last updated by  impossible 5 years, 3 months ago.

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  • #114871

    Bansaw
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    I’m seeing my doctor next week and we’ll discuss my Methlyation results further. But wanted to know if anyone (esp. impossible) had any comments on them.
    I have a few double-mutations.
    The test was performed by Doctors Data and apparently they have a few pages of recommendations that I was not faxed. What they faxed me was only the results page here.

    #114877

    impossible
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    You are highly likely having some problems related to this area of the physiology. I hope you have a good doctor who knows their methylation stuff, you are likely going to be a tough case. The mthfr 3 and mtrr a66g are both large roadblocks but with homozygous mut’s with both 158 and 62 comt genes and mao a, you are probably not going to handle mb12 or methyl donors very well. Some people are exceptions to that rule, you wouldnt know until you tried.

    Another cbs 699. Alot of chronically ill people have it but i didnt expect it to be this prevalent in this crowd. Try out the cbs protocol- no sulfur foods and add in some molybdenum and/or yucca root if you wish. If you feel better and clearer, you will know you’re expressing it and should stick with it. Its a first priority mutation anyway and you will tolerate any methyl supplementation better if it is a problem and has been resolved.

    As far as the nos mut’, no one could put it better than heart fixer, I doubt there is anyone more familiar with its implications than him, here is what he has to say:

    In a BH4 dependent reaction, Nitric Oxide Synthase (NOS) converts Arginine in to Nitric Oxide, the molecule that resists plaque formation, vasospasm, and abnormal clotting. If you can make and maintain Nitric Oxide then you will not develop cardiovascular disease. If you have cardiovascular disease and if we can successfully reboot your Nitric Oxide system, than we can stabilize your disease. Every maneuver in drug and non-drug cardiovascular medicine that improves patient symptomatic status and outcome works on this system. Every risk factor (or causative factor for cardiovascular disease) compromises Nitric Oxide generation or maintenance. NOS is also involved in ammonia detoxification, a job that distracts it from its Nitric Oxide generating duties and which uses up BH4. Without adequate levels of BH4 Nitric Oxide Synthase will not convert Arginine in to beneficial Nitric Oxide, but rather in to undesirable free radical species such as superoxide or peroxynitrite.

    The NOS D298E abnormality codes for a dysfunctional NOS enzyme. It has trouble breaking down ammonia and it has trouble generating Nitric Oxide. NOS (+) individuals are at greater risk for developing all forms of cardiovascular disease, for experiencing adverse events, and for restenosis following balloon angioplasty. A component of “a positive family history of cardiovascular disease” is related to genes coding for high cholesterol, elevated lipoprotein (a), and iron over absorption. The rest likely relates to inherited abnormalities in NOS, ACE, and the other Methyl Cycle genes. If you are NOS (+) we will pay particular attention to maneuvers designed to lower your ammonia burden, and to address risk factors that compromise Nitric Oxide. As the products of a compromised or genetically abnormal NOS system are the free radicals superoxide and peroxynitrite, aggressive antioxidant supplementation makes sense here (while a broad spectrum program of antioxidant supplementation is always wise, we specifically use Vitamin C to neutralize superoxide and 5-methyl folate to neutralize peroxynitrite). I give two separate two hour presentations on Endothelial Dysfunction, which we have on cassette tape (we will likely have a DVD presentation available late next fall). BH4 supplementation has been demonstrated to improve Nitric Oxide generation and endothelial function in individuals with risk factors such as hyperlipidemia, and we presume that it will do the same in individuals with Methyl Cycle abnormalities.

    Having both a cbs mut’ and nos mut’ is an ammonia double whammy, I urge you to try out some yucca root, you might really benefit from it. Do you have bad brain fog by chance?

    This lady summed up the acat mut’ perfectly:

    http://www.biomedheals.com/2013/11/treating-acat-mutation-mito-dysfunction.html

    Again, this mutation, if it is being expressed and is causing a problem, needs a very good doctor that is very familiar and experienced with treating this particular area of the physiology to be properly treated.

    If you have any emotional/ psychological issues, armed with the knowledge of the comt and mao a mut’s, you could possibly do well with some targeted supplementation regarding those. The couple of docs I talked to and follow regarding those will generally treat them last, fyi. Again, a doc very familiar with treating those conditions bio-medically will go a long way.

    How familiar are you with the methyl cycle and all that goes with it? Have you been to heartfixers page and how well do you understand it? You could really use an ace doctor, if you dont have one, I might be able to help recommend one.

    Just out of curiosity, what symptoms and conditions do you and your family have that are on the checklist I put together, if you dont mind?

    #114879

    Bansaw
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    Topics: 50
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    impossible;53398 wrote:
    How familiar are you with the methyl cycle and all that goes with it? Have you been to heartfixers page and how well do you understand it? You could really use an ace doctor, if you dont have one, I might be able to help recommend one.

    Just out of curiosity, what symptoms and conditions do you and your family have that are on the checklist I put together, if you dont mind?

    Thanks impossible. I am not so familiar with the Methylation process. But I have been in a brain fog for a while, and felt like a zombie for a few years.
    I have a very good doctor who has helped me, and he’s a pretty good all-round integrated medicine specialist, but I do sense that the Methylation process is not his specialty. I would be open to any specialist doctor recommendation and perhaps I could do an over-the-phone consult with him.

    I think my Methylation cycle has been broken not just from Candida but I was in Africa for five years during which time I suffered from post traumatic stress (from being in an area of high conflict), plus I contracted Endemic typhus, a bacterial infection and taken loads of antibiotics which probably didn’t help any Candida issue.

    I have taken yucca root before actually but as an antifungal that would likely disrupt candida’s biofilm (apparently). Molbydenum, I have here and take occasionally.

    I’ll have to read heartfixers page and generally become more informed about this issue, because, even I can see from my results that this Methylation cycle is a big issue for me.

    Doctors Data who did my test also suggest a protocol (which I’ve actually not seen yet), and won’t until 27th Jan. I am eager at least to get a consult with a very good Methly doctor to get a second opinion. Dealing with this is such an important step and I want to make sure I get good input.
    Thanks,….

    #114883

    impossible
    Member
    Topics: 16
    Replies: 606

    I would definitely say get on a sulfur free diet. Follow heartfixers recommendations on dealing with a cbs upregulation. You would probably see alot of your brain fog clear up from that, and it can affect all sorts of other systems in the body in various off the wall ways, so you might see some overall improvement too.

    For you, I would recommend either Dr. Jess Armine or Dr. Tony Boggess. They both have websites that are easy to find. I dont have any personal experience with Dr Armine but I have no problems whatsoever recommending him, he’s good. I do have experience with Boggess and he specializes, basically, in you. But he has a long waiting list.

    Its not going to happen overnight, but with the right protocol it looks as though you will make some positive gains with your health.

    You’re welcome

    #114917

    Bansaw
    Participant
    Topics: 50
    Replies: 106

    impossible;53404 wrote: I would definitely say get on a sulfur free diet. Follow heartfixers recommendations on dealing with a cbs upregulation. You would probably see alot of your brain fog clear up from that, and it can affect all sorts of other systems in the body in various off the wall ways, so you might see some overall improvement too.

    For you, I would recommend either Dr. Jess Armine or Dr. Tony Boggess. They both have websites that are easy to find. I dont have any personal experience with Dr Armine but I have no problems whatsoever recommending him, he’s good. I do have experience with Boggess and he specializes, basically, in you. But he has a long waiting list.

    Alas, my insurance just told me that they’ll not pay for an over-the-phone consultation.:s In my state, North Carolina, I can find a Methylation doctor about 2 hours drive away in Hendersonville. So I am toying with the idea of seeing her.

    I’ll have to have a look at the low sulphur food groups and figure out how they intersect with my Candida diet. I’m on a pretty strict diet, I would say stage II of the diet.

    Next week I’ll post my treatment protocol as I see my doctor on 27th. Thanks! I was kindof hoping that I had an issue with my Methylation last week because I was reflecting on the fact I’d reached a plateau with my Candida diet and antifungals. However, I perhaps didn’t want to see that many mutations!

    #114918

    impossible
    Member
    Topics: 16
    Replies: 606

    What is her name? What is her typical patient profile?

    The biggest part of the cbs protocol is sulfur avoidance. Supplements wont do much at all without it. There are at least a few people on here that can tell you how big of an impact this can have. Read up on the effects of excess ammonia if you need motivation to discipline yourself. I know it can be limiting and tough, but if you need it, the results are so worth it.

    I know what you mean about the impact that the results can have on you. Its kind of an odd pill to swallow. Remember though, nothing is written in stone. Look at it as more of a general recommendation. Some people have serious snp’s and have good health. The occasional comt +/+ can handle methylfolate ok (I went searching and found a few). I was going to recommend a methylation panel that measures your actual folate, SAMe, homocysteine, glutathione etc levels, if you can swing it. That would give you a better idea of where you actually are at and what you need.

    Supplements High In Sulfur

    Taurine
    Cysteine
    Methionine
    Glutathione

    Glucosamine Sulfate
    Chondroitin Sulfate and MSM

    Epsom Salts
    Magnesium Sulfate Cream

    Canned meats, Aged game
    Homemade yeast breads

    DMSA and DMPS (Metal Chelators)
    Milk thistle, Beyond C, and Heparin

    Foods High In Sulfur

    Vegetables:

    Garlic, Onion Family
    Kale
    Collards
    Pickles

    Cabbage
    Brussel Sprouts
    Kohlrabi
    Broccoli

    Cauliflower
    Bok Choy
    Mizuna
    Broccoli Rabe

    Chinese Cabbage
    Napa Cabbage
    Turnip / Rutabaga
    Canola / Rape Seeds; Greens

    Mustard Seeds
    Tatsoi
    Radish
    Daikon

    Horseradish
    Japanese Horseradish
    Arugula
    Watercress

    Peas
    Spinach

    Fruits:

    Raspberry
    Cranberry
    Currents
    All Dried Fruit

    Others:

    Vinegar (especially if prepared from wine)

    Alcohol Beverages (especially wine; not vodka – beer is less of an issue, especially German beer)

    Soft Drinks
    Animal Products
    Dairy
    Eggs

    Brazil Nuts
    Peanuts
    Soy

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