Hello all, This is a topic that people don’t talk about in Candida Forums. It is an important topic because susceptibility is very important to a successful treatment.
There are two types of antifungal resistance, the acquired and the intrinsic.
The acquired resistance can be overcome combining antifungals. The intrinsic needs a different antifungal.
For instance, Candida Krusei is naturally resistant to Fluconazole. To treat Candida Krusei you need another systemic antifungal drug. Some strains of Candida Glabrata and Tropicalis are also naturally resistant to Fluconazole. Combining Fluconazole with other antifungals, don’t correct it in these cases.
However, many candida strains develop resistance to Fluconazole during the therapy. This acquired resistance can be overcome combining Fluconazole with other drugs or natural substances. For example, Fluconazole plus Lamisil has shown to be effective for acquired resistant candida strains. Fluconazole plus Berberine has also shown synergy treating resistant strains. There are several natural substances that show synergistic effects when mixed with the azoles drugs.
This is important because many people don’t respond to an antifungal and blame it. It isn’t that the antifungal isn’t effective but the specie or strain is affecting you isn’t sensitive to it. This is even more common with natural substances.
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