I think Jorge is right. I have been doing antifungal enema’s for 2 days now and I feel actual die off. I havent felt die off in months even being on a normal healthy diet and taking large amounts of oral antifungals to check for die off. ONLY the enema’s make me feel die off, which means I have cleared candida in the rest of my body. But even chlorine dioxide gets into the bloodstream and does not target the colon, where the candida lies dorment for a chance to come back. I assume die off after enema’s mean I am targeting the base of the candida in the colon. For people with a long lasting and stubborn case of intestinal candida, the protocol might not be enough. Unless maybe if you can live like a monk for a year. But even then, when all your symptoms are gone, who knows how much candida is waiting in the colon for a chance to build up again?