For some reason I can’t open that link.
Here is some evidence I have found in my own research. It appears that, in addition to ‘crowding out’ the candida, S. Boulardii actively secretes many of the antifungal medium chain fatty acids people rely on in their treatment such as those found in coconut oil:
It has been shown that both live Sb cells and the extract from Sb culture filtrate diminish C. albicans adhesion to and subsequent biofilm formation . Thus, independently of the trophic relationships, for example, elimination from the medium of carbon source (sugars) or polyunsaturated fatty acids , Sb releases to the medium active compounds. These compounds in dose dependent manners are able to inhibit switching from budding yeast to hyphae growth. The extract prepared from Sb culture filtrate was showed to contain 2-phenylethanol, caproic, caprylic and capric acid. The highest activity reducing candidal virulence factors was capric acid (C10:0), which is responsible for inhibition of hyphae formation. It also reduced candidal adhesion and biofilm formation, though three times less than the extract. Thus Sb release to the medium other factors, not yet identified, suppressing C. albicans adherence . Capric acid acts through the activation of cAMP pathways and Hog1 kinase cascade, reducing the expression of genes of C. albicans virulence. Capric acid reduces CSH1, INO1, HWP1 transcripts. CSH1 encodes a protein related to the hydrophobicity surface of the fungal cell wall and is involved in adhesion. INO1 encodes an enzyme involved in the biosynthesis of inositol, which is a precursor components on the surface of the cell wall of C. albicans involved in the virulence. HWP1 (Hyphal Wall Protein) encodes protein present in hyphae and pseudogyphae and involved in adhesion and biofilm formation. Besides inhibition of C. albicans adhesion to epithelial cell lines, Sb living cells and compounds released to the medium, reduced cytokine-mediated inflammatory host response. In fact the IL-8 gene expression was suppressed in C. albicans-infected epithelial cells by the compounds released to the medium by Sb .
It is clear that Sb secretes many compounds and some of them may act as quorum sensing and modulate growth of other microorganisms including other eukaryotes such as C. albicans. Besides identified compounds and their activity it is clear that there are still other biologically active compounds produced by Sb which remain to be discovered .