home › The Candida Forum › Candida Questions › Sugar binge after 1 week on diet, antifungals & probiotics. Sugar addicted noob only making it worse › Reply To: Sugar binge after 1 week on diet, antifungals & probiotics. Sugar addicted noob only making it worse
And thats not even getting into the possibilities of the mycotoxin illness model of immune dysfunction or a possible overgrowth of gram negative baddies and their toxic lps’s creating a state of havoc. The more I learn, the more I see candida overgrowth as merely a symptom. Not to mention the fact how much non-IgE sensitivities you see in this crowd. In a candida specific immune environment, one would think that there would be a huge increase in IgE reactions. I see antibody related hypersensitivities everywhere, loss of oral tolerance in this crowd is of epic proportion, but most of them are non-IgE. It even seems like one could make a case that several people see a decrease in IgE reactions before infection. That is all again typical of something other than candida influencing the immune system. Of course, another persistant infection that draws an Il-4 response would subvert that effect, and that is what I at this moment attribute IgE reactions in this model too. Most likely the gram negative example used above being a probable particular influence. And hypersensitivities are not due to just gut inflammation, I know several people with crohns and have spent a fair amount of time cruising crohns messageboards and hypersensitivities, in the conexxt of oral tolerance, are practically nonexistant. I would also like to add that I do not speak in absolute terms, rather the general rule.
The typical case of someone affected by this syndrome is a depressed cell-mediated immunity and an overactive humoral immunity. This over-activity in the Th2 immune response is what cause the hypersensitive state candida sufferers have. The humoral immunity reacts to many things “normal” people don’t react Th2 is too sensitive and reinforced when Th1 is depressed.
The immune system must be balanced to function correctly.
Yes, that is exactly what i am saying. But there are many models of hypersensitivity reactions, and I am stating the one typically seen with the cell mediated deficient response to candida is one that is typical of deficient interferon gamma. This again is the prime target of certain intracellular pathogens. That low of IFN-g doesnt typically happen in Th2 driven immune systems, to that degree. And with much of a defiency in IgE class switching, thats not typical of a typical Th2 dominant immune system either.