Reply To: Ibuprofen reverts resistance to azoles

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dvjorge
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jameskep;46829 wrote: Would be interesting to see how ibuprofen would work topically as well. Topical application for inflammation might be worth experimenting?

Vaginal or anal inflammation–might be worth trying(inserting topically)? Never heard of anyone experimenting with this?

It can be used topically for microbial infections. I can image Clotrimazole cream combined with Ibuprofen cream for a resistant vaginal infection. There are studies of its use in the vagina and skin. Here are some :

http://applications.emro.who.int/imemrf/smj_2009_30_5_624.pdf

http://www.hindawi.com/isrn/obgyn/2012/673131/

See this:

The in vitro antifungal activity of econazole was notably improved by addition of ibuprofen isobuthanolammonium. Macrophage killing of C. albicans was significantly increased by the two drugs and also germ-tube formation was significantly affected. The investigators concluded that the addition of ibuprofen isobuthanolammonium to econazole provides better in vitro antifungal activity. These data suggest that vaginal infections caused by Candida albicans treated with econazole could be improved by addition of ibuprofen isobuthanolammonium. All these data support the evidence that ibuprofen has also an antimicrobial activity against Gram-positive, Gram-negative, and fungal microorganisms. These characteristics could offer a strong rationale for the development of a vaginal formulation of ibuprofen to be used in inflammatory/infective conditions involving vulva and vagina.

Jorge.