Reply To: MTHFR Results Not Too Good

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impossible
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Oh yea, you’re going to need to maintain it. In fact, depending on how strict you are, you might even notice some of those symptoms coming back when you start the methyls as you start to produce more homocysteine. That is why I recommended the tmg, it supports the “shortcut” pathway for turning homocysteine back into SAMe, leaving less to be converted into ammonia and sulfites. I dont remember if I mentioned it here, but turmeric also helps draw cysteine away from that pathway (in the transsulfuration pathway) and promotes its conversion into glutathione. Which is a total win. Plus you get all of its other benefits.