- August 12, 2015 at 5:48 pm #171621
This post is a summary of what I’ve discovered so far. Since I’ll post this on another forum[/url] and because this post will be used to explain stuff to people that have no background whatshowever, it will contain things that are obvious to most people on this forum. The end on this post will contain questions, so you don’t really have to go through the whole post if you don’t want to.
This post is rather long (sorry for that, I don’t like reading either), but it’s kind of important to go over it all since it is a coherent story. The most important info is at the end of this post. I’ve tried to be complete as possible.
When I was a kid, I was rather healthy, strong and bright. I was somewhat more anxious than other kids. I hated big crowds and I was what other people might describe as ‘silent’. In the 3rd grade, I started to get quite serious dust mite allergies. I remember that the floor of our classroom was covered with mats. Especially during the winter time, when the heating was enabled, my allergies would flare up in a somewhat dramatical way. There were times that I wasn’t able to see the board because my eyes were covered in tears and I had to use 7-8 handkerchiefs which were all wet at the end of the day. I got some relief from homeopathic drops and saline, but it only softened the symptoms.
I had swollen lymph nodes beneath my jaw and at the back of my head, which I thought was related to allergies.
Later in primary school, I started to get nausious quite frequently, especially in busses and in cars but also just on hotter days. I also had a lot of cold hands and feet. This usually appeared together with cold sweats (as in feeling cold but sweating at the same time).
Anyway, in the last years of primary school and the first years of high school, I started to get skinny to the point that people wondered whether I ate enough. I became chronically underweight and I actually started to feel ill at that time. For some reason I started to develop some form of ADD which appeared and disappeared from time to time, but not serious enough to be a big problem. I remember that I became very irritated when I was bored, which was basically most of the time. I thought a lot of courses went way too slow or were a lot of bullshit and braindead nonsense. During my whole childhood, I had a minor form of Athlete’s foot.
Another symptom I had and concerned me a bit were heart problems. Those were threefold. The first type was pain that appears on the left side of my chest and it spreads until my left ring finger. This was the type that occured most frequently, but wasn’t all that problematic. I think the scientific term is ‘angina‘. The second type is a racing heart (tachycardia). This means a very fast heart beat (110-130) for a very long time (like a few hours) without doing any excercise. This is very tiring. When this happens, I usually have to lay or sit down. There is nothing that would make this symptom go away other than just resting. It usually takes a few hours, sometimes half a day, before my heart rate would return to normal. The last time this happened was half a year ago. I’ve taken a screenshot from my measurements back then. The first measurement was 130 bpm at 17h. One hour later it slowed down to 117 bpm and stay stable for 6 hours. In the middle of that night it was 105 bpm. My normal heart rate is 68 bpm.
The third type is actually the most disturbing. It is an irregular heart rate. As far as I remember, I only had this twice. The way I can describe this is an asynchronous heart beat with occasional skips.
Some people suggested[/url] to have this investigated, but meh.
Thinking became a problem because of a symptom that most call ‘brain fog‘. The best way to describe this is ‘having a hangover without the pain’. This might explain a bit more about this symptom. There is actually a post[/url] that has examples of typical brain fog situations.
During the middle to later years of high school, my weight got better (still not high enough), but other problems started to appear. These included intestinal cramps during he day, together with sometimes serious bloating. The bloating was really bad in the sense that walking or running would become painful and definitely not pleasant. Sometimes it was possible to hear the air in my bowels by just pushing on them. I also got weird pressure headaches and symptoms that could be related to as ‘diabetes’. High cravings for sugar, feeling bad before a meal or after physical excercises, trembling and dizziness. An example of trembling:
Most of these symptoms got much better after a meal, but most of them didn’t disappear completely. Acne appeared and disappeard (after I stopped eating hydrogenated fats) and I was also tired during the day, although I always slept 8 hours a day. As a result I also looked very worn out. At some point someone made the remark that “I had a serious party last night.” even when this wasn’t true at all. I never went out during high school because I was tired most of the time. My liver would also hurt, like it wasn’t able to keep up with detoxification.
I’ve never complained about anything and I probably never will, but this kind of attitude didn’t fix all these problems. I thought these things would go away automatically. Obviously this wasn’t the case. It took me until the end of high school, before I started to see some doctors. Mainly because of digestive issues. The first doctor thought I was making everything up and thought it was ‘all in my head’. The second one thought my bowels were ‘stressed out’ and prescribed me something that would relax them. I knew that this was nonsense and I threw away the prescription. He also told me that trembling was ‘in my nature’ and that ‘there was nothing that could be done about it’. He prescribed some vitamins for my fatigue. I didn’t pick them up either. The third doctor was a homeopath which thought I had ‘adrenal fatigue’ (which is actually a possibility) and gave me some something that didn’t really do anything. The fourth doctor was an osteopath. He thought that my liver was ‘overworked’ and gave me some brewage that he probably made himself. I think it contained things like artichokes and other herbs (like swedish bitters). He also found out that I supposedly had a bunch of allergies, especially cows milk, gluten and certain types of meat. Allergies would make a lot of sense. Mainly because my bowels were very irritated as in IBS. Fast food would give me terrible symptoms. A regular western diet was very bad for me, but on the other hand it is very bad for everyone. Avoiding gluten and milk improved my symptoms somewhat but not all that much. The fifth doctor was an internist (a doctor who is specialised in internal diseases). This was in 2012. She did a blood test for a lot of stuff and she discovered two things. First of all, my vitamin D3 levels were too low 19.6 ng/ml [40-100] and the IgG marker for candida was out of range 142 mgA/l [< 120]. There were undigested muscle fibers and fats in my stools.
The skin test for allergies pointed out allergies for E210-E219 preservatives.
Finally, the first real discovery.August 12, 2015 at 5:50 pm #171622
Candida is a fungus that naturally can be found in everyone’s digestive tract. In some individuals, this infestation goes out of control. Mainly because their immune system can’t keep the infestation under control or because their intestinal environment allows the fungus to become pathological (the lack of probiotics). Most people who suffer from a candida infestation have a history of antibiotic use.
Candida leads to cramps, intestinal malabsorption, diarrea and other digestive issues. It makes the walls of the intestines permiable which results in small food particles that enter the bloodstream. This is why it is also called ‘leaky gut syndrome’. The small food particles that enter the bloodstream can trigger an allergic reaction which can disappear and appear again over time. This can make treating candida very difficult.
Whenever the infestation goes ‘out of control’, the immune system intervenes and starts attacking the candida strains. Whenever candida dies, about 79 amount of different toxins get released which have to be cleaned up. Some of these chemicals cause dizziness (ethanol is one of them), others cause brain fog (acetaldehyde). All these symtpoms can have huge implications.
Allopatic medicine doesn’t recognize candida in healthy individuals, only individuals that have a serious condition like aids or undergo chemotherapy. Candida occured in one of the episodes of House M.D. as a secondary disease.
We live in a society where people assume that everyone is healthy. And if you are not you can just go to the doctor, they will fix your problem right? Allopatic medicine has no idea how to cure chronic conditions, like depression, ADD, chronic fatigue, ibs, high cholesterol, … because the solution to these diseases can not be found in just one wonder pill. All they do is symptom management.
I started with diflucan which is an antifungal. This didn’t do anything. Then I got some other antifungals (caprylic acid) and digestive enzymes and I had to change my diet. When I did that, I noticably got better. A lot of symptoms that I related to as ‘diabetes’ improved in a serious way or even disappeared. Even my headaches got better. It happened a lot that when I took the train or the bike, I had to sit down for a while to recover, sometimes even up to half an hour. I felt like a 70 year old. This symptom disappeared too. The most noticable symptom that was still present was sugar addiction.
I followed her advice for about a year. Most symptoms stayed the same during that peroid, but never completely disappeard. Everytime I ate something I should not eat, I noticed serious die-off. This was most noticable by flu like symptoms/very hot face. This is why I started to do some research on the internet. I found a forum called ‘The Candida Forum’. One of their users had a ‘protocol’ which was very popular amongst their members. It included a wide range of antifungals, probiotics and a very strict diet. It started with a ‘cleanse’ or a period of detox. I decided to commit completely to this protocol. The period of detox (of a few days) had a very strict period of only vegetables. I had to cut out all sources of sugar and protein. It also demanded to take some supplements for liver support (like molybdenum and milk thistle herb), as well as the use of bentonite clay to clean out your bowels. After this period, small amounts of eggs and later chicken may be added. In the meantime, I found out that I had a serious deficiency in stomach acid. Stomach acid is necessary to break down proteins. If the proteins are not broken down in a correct fasion, the food you eat and especially the sugars start to yeast in your system. This leads to massive bloating. I had to add 13 grams of hydrochloric acid to fix this. You have to realize that HCl comes in capsules of 1 gram. The bottle adviced to take only 1 capsule per meal. The bloating disappeared.
The diet demonized fruits because it was a source of sugar. The beginning of this diet was very hard, because it lead to serious headaches and serious fatigue. It took me serveral months to recover from this to the extend that I failed all my exams in that period. This meant that I had to do them all over and I lost 1 year of college.
Later in the diet I added some probiotics in pill form as well as kefir which I made myself. I used organic goats milk for this. Milk isn’t good for people with digestive issues, but I felt that it really helped to some extend. It would be much better to use raw milk, but we can’t have that, because the government has to protect us, right? The probiotics in pill form did absolutely nothing. The antifungals included caprylic acid, oregano oil, red thyme, coconut oil, SF277, … I never used pharmaceutical grade antifungals like nystatin or diflucan during this protocol because candida can adapt to these antifungals. Later on, I added bouilardii which is a fungal strain that competes with candida and is considered to be a probiotic. This helped me a lot.
I followed the strict diet for quite some time but it didn’t take long before I realized that it would not solve the problem. I actually got really far in the diet without cheating a lot. The treatment for a chronic candida infestation is difficult because there are many factors that have to be considered and it may have many causes. As long as the cause of the infestation is not addressed, the infestation will reappear, no matter how many antifungals and probiotics you use.
I was desperate. I had no more ideas. There were no doctors that could help me. I feared that this problem would never be solved and I had to change my diet permanently. Then I found a topic[/url] on the candida forum called This is a MUST read for everyone with CANDIDA.. It stated that most people with a candida infestation had mercury poisoning. The author of the post claimed to have cured himself this way.
He refered to Amalgam Illness, diagnosis and treatment, a book of Andrew Cutler who has a PhD in chemistry. I immediately read his book. The similarities of the symptoms that are described with my own symptoms were pretty accurate.
Gastrointestinal and endocrine problems, fatigue, inability to find the right words, brain fog, irritability, timidity or shyness, frequent headaches (especially with excessive stimulation), depression, anxiety, dizzyness or poor balance, tinnitus, diarrhea or constipation, cold hands and feet, Athlete’s foot, dry ankles, waking up late and staying up late, light sensitivity, myopia, loss of smell and hearing and understanding speech, night sweats, racing heart (tachycardia) or hart pain (angina), underperforming thyroid (resulting in overall low body temperature and endocrine function), excessive urination, weight loss, hypoglycemia, low blood pressure, hypogonadism, bed wetting (in children), unusually early or late puberty, allergies or asthma, blurred distance vision, metallic taste in mouth, leg cramps, chemical sensitivity, muscle tremors, speech that is hard to understand or without intonation, loss of coordination, fearful dreams/nightmares (children sleep with a blanket or their hands above their head), paleness, low testosterone/estrogens/androgens, gastrointestinal pain and gas, flattened emotions, yeast overgrowth, fibromyalgia, chronic fatigue.
I agree with 90% of these symptoms. Symptoms that I had and that are rather specific for mercury poisoning are light sensitivity, dry ankles, racing heart (tachycardia) or hart pain (angina), weight loss, unusually late puberty (I was 16), metallic taste (only as a child) and nightmares (Especially as a child. As a matter of fact, I did sleep with a blanket above my head.).
By the way, the rethoric in this book is amazing.
This is not the first time in the history of modern medicine that a very obvious disease was belittled and ignored for political reasons. Until recently it was believed that ulcers were entirely psychosomatic. Ulcer sufferers underwent prolonged treatment, were seldom cured, and often ended up under the surgeon’s knife. After years of intense criticism and ridicule – about 20 years after the research was published – it has fomally been accepted that most ulcers are due to helicobacter pylorii infection which can be easily cured with appropriate antibiotic therapy. Yet it is still common to find physicians who still treat ulcers by prescribing acid suppressors – as if they resulted from too much stomach acid.
Cutler included a diagnostic checklist for mercury intoxication. From the 58 items, I was able to verify 27. 13 of them were positive, 14 negative which is indicative for mercury intoxication.
Furthermore, I’ve always had a weird ‘burning’ sensation in my head which I could not place. I thought it was related to headaches. One day this symptom was easily distinctable from regular headaches. I googled ‘burning brain’ and this is the first website I found. This couldn’t be a coincidence anymore.
I wasn’t satisfied with the checklist and all the matching symptoms. I had to be sure and ordered a hair test. I read his other book, Hair Test Interpretation: Finding Hidden Toxicities to understand how to read a hair test. These are the results of the hiar test:
It’s not all that difficult to read a hair test, but you have to know what you have to look for. There are two things that can indicate mercury intoxication, high mercury levels or an unlikely mineral result. If a hair test is statistically unlikely, it may indicate ‘deranged mineral transport’ caused by mercury poisoning. I’ve given a mathematical explanation on my blog[/url]. Either way, having 6 bars or less to one side has a statistical probability of 2.6%. This means that 1 in 40 will have this kind of result at random. In conclusion, the results of the hair test are ‘highly suspicious’. Because there is suspicion of deranged mineral transport, the results of the toxic metals are not reliable.
Shortly after that, I started chelation. Chelation involves the use of chemical compounds that have the ability to remove heavy metals. For mercury this is DMPS, DMSA or ALA. Alpha Lipoic Acid is a natural antioxidant that can cross the blood-brain barrier and is the most important chelator. DMSA can also chelate lead. Chelators have a certain half life. This means that the amount of this product halves after every x units of time. Chelators have to be taken frequently, otherwise the mercury gets redistributed without being moved out of your system. The half life of DMPS is 6 hours, for DMSA this is 4 hours and for ALA this is 3 hours. This means that DMPS have to be taken every 6 hours, ALA every 3 hours. Also at night.
Before engaging in chelation, one must remove all amalgam fillings because they contain 50% mercury. Especially chelating with ALA while having amalgams can make a patient worse.
According to Cutler, amalgams are the source of most mercury problems. There is a lot of debate about wether this is the case. There are a few studies that confirm that amalgam fillings significantly increase the level of mercury in saliva and feces, significantly impair kidney function in sheep and increase the amount of mercury in plasma and urine a 5 fold for users of nicotine gum. Other sources of mercury include fish. The mercury concentrations in fish increase about 4% per year caused by coal power plants, especially in big fish like tuna. Another source of mercury are vaccines.
There is no real safe limit for mercury. The EPA has determined a ‘safe limit’ of 0.1 micrograms of mercury per kilogram of body weight per day, which is easily exceeded by either source.
Norway, Sweden, Denmark and Germany have banned or limited the use of amalgams because it is unclear whether they are safe.August 12, 2015 at 5:51 pm #171623
Before I knew anything about mercury intoxication, my dentist automatically removed all amalgam fillings and replaced it with white composite fillings. I know that they contain BPAs, but it’s better than having a neurotoxin in my mouth right? Either way, I don’t have them anymore which is a good thing. I don’t know whether they are removed in a ‘safe’ way. I guess not, but whatever.
So far, I’ve done 20 chelation rounds. I started off with DMPS only and then incorporated ALA. I substituted DMPS with DMSA once I ran out of it DMPS. I’ve included several breaks in between chelation rounds. There is a gap at the end of 2014 and another one in March 2015. The main reason for these gaps is the fact that chelation can be kind of heavy. It is true that chelating with DMPS is less intruding that chelating with DMSA. I’d really recommend DMPS over DMSA if you have the money available to use this.
Between 1 December and 9 December I broke my arm and they immediately gave me a tetanus vaccine. I was under the assumption that most of the vaccines didn’t contain mercury anymore. Apparently, I was wrong. The night after I got the vaccine was horrible. I was nauseated, dizzy, had a headache, felt very ‘weird’ and couldn’t sleep. I also had a fever, although I had almost no pain.
After I was released from the hospital, I immediately restarted chelation with DMPS. The fever continued for 2 more chelation rounds. I didn’t have a fever in between those rounds.
During chelation, I take zinc (50 mg), vitamin C (as ascorbic acid) (1-2 g), a B50 complex, vitamin E (100 IU) and selenium (200 mcg).
A lot of symptoms improved during chelation. I feel best at the first day of each chelation round. This may be because of the antioxidant properties of ALA. On the last day, I always feel like my brain is being squeezed like a sponge. I’m pretty sure this has nothing to do with the interrupts in my sleep.
The biggest general improvements have been in the area of digestion. The general advice is to clean up the gut before starting chelation. I’ve tried a lot of things to accomplish this. Nothing seemed to work long term. The other way around is the way to go for me, chelate in order to cure my gut. I can basically eat anything now without having issues the day after. Sugar doesn’t seem to affect me anymore. The only thing that I avoid are animal proteins. I eat a mostly vegetarian diet with some exceptions of fish and chicken once and a while (maybe 1-2 servings per week), although I don’t feel that I need it. The main component of my diet are fruits. Athlete’s foot is almost completely gone, brain fog is gone, trembling is mostly gone, sugar addiction is gone, headaches are gone, heart problems haven’t occured anymore. I’ve gained a significant amount of weight. Before I started chelation, I weighed 64 kg. For a height of 192 cm, this results in a BMI of 17.4 which is underweight. Now I weigh 70 kg (BMI = 19). My ideal weight is around 80 kg. I guess this is because my gut has healed significantly.
The only symptoms related to candida that I still have are a warm head after die off and oral thrush when I eat too much prepared foods.
Other symptoms that are related to energy and mood have improved, but way slower than I expected (while the gut issues have improved much faster than anticipated).
When I found this forum last year, I found out about the connection between mercury poisoning and methylation problems, so I ordered a test from 23andme. I’m not gonna explain methylation here. This is a very simplified explanation. This a more extensive explanation. The most important thing you have to know is that it is involved in the production of neurotransmitters and catecholamines (like serotonin and dopamine) and also detoxification and the reduction of oxidative stress. It is also connected to the krebs cycle (energy). The main components that are used by the methylation cycle are methylfolate and methylcobalamin.
If your methylation cycle doesn’t work correctly, it may lead to a wide range of diseases like alzheimers, depression, autism, bipolar disorder, heart disease or stroke, chronic fatigue, … Having methylation mutations is not uncommon. About 50% of the population has at least 1 mutation in the most important gene, C677T. It’s mainly the combination of mutations can cause problems. Certain mutations are protective.
These are my results (+ is a mutation, while – is the normal allele):
MTHFR C677T (or MTHFR in general) converts converts folate into methylfolate. This product breaks down homocysteine and produces methionine.
The MTRR genes are responsible for the recycling of methylB12. MTRR is negatively impacted by mercury. (Having mercury intoxication is like having extra mutations.)
The lack of B12 will make the krebs cycle run in the reverse direction, which can be aggravated by aluminium.
Lithium enhances the transport of B12 and folate into the cells.
A MTRR A66G mutation increases activity of the enzyme. It’s going through B12 faster which results in lower levels of lithium and methylB12.
This is also true for the CBS gene. A mutation in this gene makes the enzyme work faster. CBS converts homocysteine into cystathionine. The pathways that are linked to CBS are the transsulfuration and glutatione synthesis. It eventually raises ammonia levels and hydrogen sulfate which both lead to brain fog. CBS depletes glutathione as well as homocysteine and soaks up methyl donors. Ammonia depletes BH4 levels. SUOX is needed to convert sulfites. Sulfites decrease ATP, glutathione and blood sugar. SUOX is inhibited by heavy metals and requires B12 and molybdenum to work. Molybdenum is also used by people who have a candida infection. The aldehydes that are produced by candida must be detoxed with molybdenum and can therefore impair SUOX function.
The BHMT genes are responsible for the ‘shortcut’ route and converts homocysteine directly into methionine without the need for methylB12/folate. This route is of less importance because it is not active in the brain. People with BHMT mutations have more homocysteine available which leads to a higher CBS ‘drain’.
An important gene on this panel is COMT. The COMT enzyme is responsible for the breakdown of dopamine and (nor)epinephrine (= adrenaline) by adding a methyl group to these compounds. People who have COMT +/+ or +/- have a high supply of dopamine. The problem is that dopamine feeds back and inhibits itself. People with COMT+/+ end up with mood swings. On top of that, people with AHCY mutations might have an extra inhibition of COMT. While COMT only has a small influence on the methylation cycle (people with COMT +/+ have more methyl donors available), it is a serious limiting factor on how much methyl donors a person can tolerate.
Furthermore there is an interesting correlation between COMT and melanin levels. Melanin is what gives hair and skin color and is produced as a response to UV radiation. If dopamine levels are too high, not only the dopamine receptors are inhibited, but also the enzyme that produces dopamine is. As a result, when dopamine levels are too low, a backup enzyme (tyrosinase) is being used to produce dopamine. This enzyme is also responsible for melanin production. What is commonly seen is the fact that people with COMT mutations have a lighter skin or hair color. COMT is also responsible for the processing of estrogens.
Vitamin D is important with regard to COMT activity. Vitamin D reduces thyroriduxine reductase. Because COMT and thyroriduxine reductase share the same promotor, an increase in vitamin D will increase COMT activity.
People with COMT mutations are prone to mood swings. There is a correlation between COMT downregulation and bipolar disorder.
Most of this information comes from the talks of Dr Amy Yasko. You can find them on vimeo on her channel.
The talk that is most important in my case is the one on COMT.August 12, 2015 at 5:53 pm #171625
Current methylation supplements:
Hydroxycobalamin 1000 mcg (sublingual): MTRR
Methylfolate 200 mcg: MTHFR
Methylcobalamin ~50 mcg: MTRR
Phosphatidylcholine 300 mg: BHMT and CBS
Trimethylglycine 500 mg: BHMT and CBS
Vitamin D3 5000 IU: VRD Taq. Dosage depends on the season. Obviously more during winter than during summer.
I currently can’t tolerate methylcobalamin in high doses. It makes me ‘mixed’ or hyper without really giving energy.
Current support for candida:
Molybdenum 150 mcg: Supports SUOX and combats candida die off.
Saccharomyces Boulardii: This is a competing yeast strain and ‘eats’ candida. It is considered to be a probiotic.
Chromium 200 mcg: Improves blood sugar metabolism.
Current support for COMT:
GABA 500 mg: Controls the release of dopamine.
Magnesium Citrate 500 mg: Improves to function of GABA. I also use this to combat leg cramps (especially during night). It is also possible that a lower protein diet could have solved this.
Lithium orotate 10 mg: This dose is much lower than used in bipolar disorder, but it seems to have a significant effect.
L-Tyrosine 500 mg: Precursor of dopamine. Started it only recently. It seems to give me more motivation and it makes me more awake. It seems very effective to counter low periods. I’m curious whether the effect stays long term. If I take 2 doses, I get a headache.
Manganese 15 mg: Supposed to reduce bowel inflammation and it improves SOD2.
Vitamin C 1-2 g: General antioxidant
Melatonin with B6 3 mg: Sleep
Glycine 2 g: Amino acid. I feel no difference on this product, so I’m gonna stop using it once the box is empty.
Ebastine 20 mg: H1 antihistamine for my dust mite allergy
Fluticasone furoate 27.5 mcg: Corticosteroid for my dust mite allergy
The combination of the two work very well.
Supplements/drugs that I used to take (and did work):
Oregano oil: antifungal
Red Thyme: antifungal
Chia seeds: improve bowels
Bentonite clay: bowel detox
Dandelion root: liver detox/support
Coconut oil: antifungal (still take it once and a while)
Milk Thistle: liver detox/support
Betaine HCl: stomach acid
Ashwaghanda: adrenal support
Iodine: Thyroid support
Supplements/drugs that didn’t do anything:
Swedish bitters: enzymes
MegaFlora: (very expensive) probiotic
Grapefruit Seed Extract: antifungal
5-HTP: serotonin precursor
Adrenal Cortex: adrenal support
Phosphaditylserine: BHMT (Apparently this lowers cortisol levels, so this is what I dont’t want.) PS: I never used it in my current methylation program, so I don’t know the effectiveness.
I tried some NAC a few weeks ago, but it caused nightmares. The effect on my overall wellbeing have been mixed. I’m gonna leave it out for now.
My most important message is that probiotics didn’t do anything (and are expensive).
Two things have improved since the start of methylation support, energy and mood. I don’t know if I can improve energy levels even more. Mood has improved in a weird way. I’ve had mood swings in the past, but I always had a ‘low’ mood. My mood didn’t go up in a consistent way. I still have ‘low’ episodes (not that bad anymore), but I have more periods of normal and even ‘high’ episodes. I guess this is because methyl donors destabilize dopamine levels. Apparently trembling and lack of coordination and balance can be caused by low dopamine.
The original plan was to do 100 chelation rounds, but that may be too much. I’ve stopped chelation temporarily, in order to figure out the correct methylation support in the hope to speed up the process of chelation. The plan is to do a functional methylation test to optimize methylation before continuing chelation. Either way, Cutler doesn’t believe methylation makes a difference. But I believe that fixing methylation can speed up the healing process. I expect that I don’t need any support for methylation once all mercury has been cleaned up, maybe only a ‘clean’ diet. We’ll see.
Someone pointed out pyroluria on my thread about bipolar. Pyroluria is an abnormality in hemoglobin synthesis. Pyroluria can be cause by genetics but also by heavy metals. It depletes zinc and B6 (CBS uses up B6 and BHMT uses zinc) and it results in a form of anemia and low iron levels. Maybe that is a possible explanation for my rather low ferritin levels? The most outspoken symptom of anemia is a pale skin and a dark color under the eyes. A lot of the symptoms between pyroluria and mercury intoxication are very similar, although the pyroluria symptoms seem more specific. There is an interesting post on curezone which explains a correlation between low ferritin, low thyroid and adrenals and a chronic candida infection. I know that I had to take iron supplements in the past. One of the symptoms of anemia are palpitations.
The plan for now:
Do a functional methylation test.
Do a pyroluria test.
Then follow one of the methylation plans on this forum.
Additional results that can be useful (not mentioned in this post):
Ferritin: 33 mcg/l [22-275]
Serum B12: 227 ng/l [> 187]
Serum folic acid: 7.0 µg/l [> 3.1]
IgA: 215.1 mg/dl [70-400]
IgG: 1174 mg/dl [700-1600]
IgM: 73.1 mg/dl [40-230]
IgE: 29.2 kU/l [< 114]
Complement C4: 11.9 mg/dl [15-45] (Dunno what this means. Has to do with immune function?)
Rast d202 nDer p1: 1.8 kU/l [< 0.1] (marker for dust mite allergies)
Rast d2 dermatophagoides farinae: 2.24 kU/l [< 0.10] (again dust mite allergies)
Rast d203 rder p2: 2.45 kU/l [< 0.10] (same)
Wheat f4 IgG: 3.38 mgA/l [< 7.76]
Tomato f25 IgG: 6.50 mgA/l [< 7.06]
Celery f85 IgG: 4.96 mgA/l [< 7.06]
Avocado f96 IgG: 4.72 mgA/l [< 7.06]
H. pylori IgG: negative
TSH: 1.87 mU/l [0.35-4.94]
Leukocytes: 3080/mcl [3700-10000] (Apparently less than 4000 is considered ‘low’. A vitamin B12 deficiency could be the cause here.)
Lymfocytes: 44.4% [16-45] (High count is usually a sign of a viral infection?)
Monocytes: 9.4% [< 12] (Levels above 8 are high. Chronic inflammation is one of the causes.)
Neutrophil granulocyte: 1460/µl [1340-5860] (Levels beneath 1700 are considered as ‘neutropenia’. Vitamin B12 and folate deficiency is one of the possible causes.)
What is the connection between the methylation cycle and histamines?
According to MTHFRsupport, I have a slow liver phase II detox with regards to phase I. An increase in B vitamins speed up phase I, which increases the intermediates and thus oxidative stress. How important is it to fix this? Do I need to fix this before methylation?
Has anyone tried to avoid phenols (with regard to COMT)?
What kind of functional methylation test should I order? I’m located in Europe.
What other tests might be helpful? Maybe serum amino acid levels? T3/T4?
Are there other things that genetic genie doesn’t report that might be intresting, like GCH1 and SHMT? Or are they not all that relevant?
It is possible that I forgot to include some things in this post. But it is already way too long, so I’m gonna leave it as it is.April 17, 2016 at 8:25 am #172382
It’s been a while since I’ve given an update. I’ve come to new insights. Foremost, I’ve been completely wrong about half my first post. I’ll explain in a moment what I was wrong about and why.
A few months ago, @caladonia made a reply to my thread and he mentioned pyrrole disorder as a cause of bipolar. Pyrrole disorder (also called pyroluria) is a metabolic disorder in which the liver produces too much pyrroles. This is a compound used for the production of hemoglobin. Pyrroles tend to bind themselves with certain minerals and vitamins, mainly vitamin B6 and zinc, but also magnesium and manganese. Zinc is used in a wide range of enzymes as well as the production of neurotransmitters and testosterone. B6 is necessary for the transulfuration pathway to work and is also used to convert Glutamate into GABA. GABA is what slows down neurotransmitters and it has a calming effect. Glutamate is excitatory and causes awareness. Most people with anxiety problems have too much Glutamate or not enough GABA or both.
For a full list of symptoms see here.
Not long after I stopped the chelation protocol, I redevelopped some form of digestive distress. It took a while to figure out what was going on. Turns out I only took zinc during chelation itself and not in between rounds, so also not during the long break I was/am in. The first thing I did was retaking the B complex just to experiment what would happen (no active B forms in this one). The difference was there but it wasn’t massive. I felt somewhat better for sure. I ordered p5p (which is an active form of B6). The difference was about the same. Mood swings decreased, anxiety went down. No more nightmares or vivid dreams. So I slowly upped my zinc dosage from just 50 mg to 150 mg right now.
Right after chelation, most of my digestive issues were gone, but not all of them. Right now they are gone 100% 🙂 I can eat everything I want inluding fast food like pizza and hamburgers. The only thing that I still avoid is pure sugar. Other types of sugar are fine (mostly). So I can eat bread and potatos without much problems. Despite the fact that my digestion is ‘fixed’, I still have die-off from candida which I don’t completely understand. I know that a fungus infection can be located in other locations than the digestive tract. It can infect other organs as well (liver, prostate, galbladder…). The die off I still have is limited to just an hour or so per day, rarely a whole afternoon. I feel like this is highly dependent on the amount of rest (sleep) I have and stress levels. The die off used to be something permanent which was horrible.
Remember that I mentioned allergies? They are all gone (except dust mites). Including problems with milk. According to Promeathase, I should have the ability to digest milk. I found it kind of odd that this was a problem. I have all the ‘good’ gene variants for digesting lactose:
There is an other remarkable thing that has changed. The amount of hair on my chest has more than trippled. I guess testosterone levels are finally starting to rise. I see this as an indication that I’m moving in the right direction. Testosterone is highly zinc dependent. It’s also true that testosterone blocks the transsulfuration pathway, hence lowering glutathione production. It’s possible your body will lower testosterone in order compensate for low glutathione?
There is not a whole lot of research done about pyrrole disorder. The best information that I can find is the presentation from dr Klinghardt. I know it’s a 2 hour video but it’s explained in a very easy way.
There also seems to be a connection between candida and pyrrole disorder. I’ve found an ‘aternative’ website that makes the connection between a candida infection and pyrrole disorder, both promoting each others presense. It’s actually the only source I found that is so complete. This article is also worth reading.
Foremost, the zinc deficiencies that are caused by this disorder can cause massive digestive distress (because of the impaired enzyme production). When other factors like stress, heavy metals, a bad diet (and possibly antibiotics) are present, the yeast form of candida (which is present in everyone) will transform into its fungal form. This makes a candida infection not a disease, but part of a larger chronic problem. Large pieces of candida will cover the intestinal wall making holes in it causing ‘leaky gut’ and inflammation. This intestinal permeability allow small food particles to enter the blood stream causing a wide range of symptoms, mainly food allergies. Candida toxins absorbed from the intestines into the blood disable much of the energy production in the brain, muscles, connective tissue and in the mitochondria, but also in the liver, which makes the impaired heme production much worse. Waste protein block up capillaries and brain cells. This results in a severe energy deficiency in parts of the brain.
Most important symptoms: abdominal pain, neuropathy, psychiatric disorders (anxiety, schizophrenia, bipolar disorder, autism, dementia and obsessive compulsive disorder), tachycardia (fast heartbeat), severe photosensitivity, anemia, liver problems, psoriaris, weak connective tissue and overreaction to alcohol and other drugs.
Pyrrole disorder is mainly caused by candida overgrowth, certain microbes, viruses and borrelia (lyme).
Pyrrole disorder that is acquired can be inherited, but the opposite is also true. If pyrrole disorder is cured, then it is no longer inheritable?
Without heme, cells cannot generate energy from oxidizing food. Depression of heme production leads to serious metabolic defects with anaemia, mitochondrial and neuronal decay, mental-emotional problems and overproduction of nitric oxide. Underproduction of oxidative energy in muscles causes weakness, especially during extended exertion after glycogen has been used up and mainly lactic acid is generated. The combination of these factors can lead to fatigue, muscle pain and muscle cramps. The heart is an essential muscle and may compensate for the lower output by becoming enlarged.
Another factor is a decreased generation of body heat. When the outside temperature drops so that hands and feet become cold, central body heat is preserved by greatly restricting blood-flow to the extremities.
From this it is easy to see how the disturbed production of heme has wide-ranging negative effects on all body functions, even before taking the serious vitamin B6 and zinc deficiencies into account that are created in this way. Deficiencies of vitamin B6, zinc and biotin also directly reduce the synthesis of heme, their deficiencies increase stress levels, causing weak adrenal glands, and stress independently degrades heme. It is a vicious circle. Further, it is known that heavy metals, especially mercury, tend to disrupt the porphyrin metabolism and increase heme degradation. Heme depression increases leakage of oxidants from the mitochondria, thereby causing oxidative damage to cells and unsaturated oils.
P5P deficiencies are associated with lower glutathione.
Reduced heme production means reduced catalase production. Catalase degrades hydrogen peroxide. Hydrogen peroxide is what is used to ‘color’ hair blond. It simply causes depigmentation by destruction of melanin. Furthermore, melanin is rich in zinc. People with pyrrole disorder have a tendency to be pale.
While having a low blood pressure when young, this blood pressure will rise over time because of arterial congestion.
Some proteins can clean up pyrrole waste. These are serrapeptase for cleaning skin, muscles, joints and other tissue from pyrrole residues and other accumulated wastes, nattokinase for cleaning the blood vessels, and at times additional bromelain and possibly papain for general clean-up of protein residues.
There are several ways in which pyroluria and Candida, individually and jointly, affect the brain. There is the deficiency of neurotransmitters caused by P5P and zinc deficiency, the blockage of the mitochondrial oxidative energy generation by chemicals produced by candida and other microbes, and there is the clogging up of capillaries and brain cells with inflammatory and acidic pyrrole-based waste protein. The combined effect of these assaults is severe energy deficiency in parts of the brain in addition to a lack of proper nerve transmission. Problems are intensified by commonly existing multiple allergies and mercury toxicity. Even relatively young individuals with severe inherited pyroluria may accumulate high levels of waste proteins in brain cells as is typical for individuals with dementia, Alzheimer’s or Parkinson’s disease.
Blackouts or ‘grey-outs’ tend to be a common stress response of sensitive individuals with uncontrolled pyroluria. Stress, just like coffee or sweet food, strongly increases the blood sugar level in preparation for physical action. But if no such action happens, the pancreas releases an excessive amount of insulin in response to the elevated blood sugar level. This drives the blood sugar down too low which, in association with the resulting low blood pressure, causes severe lack of energy in the brain. Affected individuals may end up in the medical system with lots of X-rays, scans and other tests without finding a cause.
All problems are much worse if there is in addition mercury toxicity, but attempt mercury removal only after pyroluria and Candida are under control.
I don’t know how much of this information is correct. But it seems to describe a huge part of my symptoms pretty accurate. Symptoms:
Pale skin. Especially as an infant.
White spots on the fingernails (leukodynia) are a very strong indication of this problem. This is a picture that was taken a few weeks ago. Even after some moderate zinc supplementation. I used to have them in abundance (and much larger) as a child. About half of people with pyrrole show these white spots.
Trouble sleeping and going late to bed.
Rarely any dream recall.
Very bad tolerance to stress.
Severe anxiety as a child.
Great sensitivity to light. Snow during a sunny day or white clouds hurt enormously. Also some sound sensitivity. (Both could also be related to something else, see later.)
Cold hands and feet. (Limited body heat generation might be the reason why I’m doing worse during winter time and not necessarily because of low vitamin D. This also explains normal thyroid TSH levels, so probably no thyroid problem.)
Neurological pain, like everywhere.
A lot of these symptoms are partially stress dependent.
Pyrrole is often present in Multiple Sclerosis.
For a more more psychological point of view: click. Of course the biochemical explanation is the only relevant one.
Pyrrole disorder doesn’t explain everything. There are things that are probably caused by something else. I’m still missing a piece of the puzzle.
To be honest, doing chelation without medical supervision is kind of madness. Especially mentally this is extremely demanding. I had periods where my thinking process was completely blocked. On the last night of most chelation rounds, I was usually so exhausted that I just slept through my alarm, missing the dose I had to take. I wish I knew about this a long time ago, then I could have fixed this first. Mistakes were made…
Pyrrole disorder might explain the low white blood count. 3000 is really low. According to Klinghardt: “The white blood cells are the last things that looses to zinc. If that goes down, it’s really really bad.”
Something else Klinghardt said: “There ain’t such a thing as indigo children. This is all way of rationlalizing that we screwed these children up and we are trying to make it something sacred so we don’t have to do anything about it. These are children that we hurt really really badly. And the indigo children look is a KPU look. And that goes away when you treat it. They become normally tanning children that don’t look so transparent like you can look through them.”
This is kind off odd, but it could just be coincidence.
One thing my mother told me recently: “The only thing you did as a baby was eating and sleeping. I always wondered why you slept so much.”
Both sources are talking about lyme as a major cause of pyrrole disorder. I hope this is not the case because it is a hard to cure.
So far, I’ve had very good results with p5p and a B complex, together with zinc. I also tried nattokinase and serraptase. My first impression is that they are very calming. They also seem to have cured some skin problems (coarse skin), but that’s the easiest thing to get rid of. I guess other things will take much longer.
I recover faster from candida die off. Once the die off stops, I don’t feel terrible anymore after about half an hour.
Either way, whatever I do, I’m lost if I don’t sleep enough.
Things I was wrong about:
Pyrrole disorder is a way more complete description. It’s actually overwhelmingly accurate in my case. What I considered (hypo)mania might might just be normal after all and be periods of mental clarity and lack of brain fog and neurological problems. If you’re sick for so long, it’s a bit hard to know how being healthy feels like.
I think there is also an other factor at work, inflammation.
The reason why lithium helped is because it is protective for a wide range of stuff[/url]. I now only take it once a week, until the bottle is empty.
I dedicated a whole part of my first post try to explain how genetic mutations can lead to methylation problems. I’m now convinced that this is highly inaccurate. Genetics is almost never the cause of any disease, unless you are very unlucky. There are only genetic tendencies, but as long as there are no bad environmental factors, they are not really relevant. Everyone has genetic weaknesses somewhere. The question is rather whether they are being expressed or not. Furthermore, most of the so called ‘mutations’ are just polymorphisms, so they are not necessarily malignent. Take for example the C677T gene. About 10% of the Western population has a double mutation and most of them are doing perfectly fine, more than 50% has at least 1 mutation. Overall, they have a lower output of SAMe, but they have more glutathione available. Which one is better? You tell me. Only very unfortunate combinations or mutations that have an occurance in less than 1% of the population might be the only thing that is worth concidering.
Genetics can be helpful if you want to cure yourself, but they are unlikely to be the cause of disease.
To go over them quickly:
COMT V158M++ (~20%): Advantage in memory and attention tasks. Higher dopamine levels. COMT–: More stress resistent. Promethease sees ++ as beneficial.
MTRR A66G+- (~30%): Normal.
MTRR K350A+- (~20%): Lack of research.
MTRR A664A+- (~40%): Possibly need more B12. ++ is kind of rare.
BHMT-02++ (~10%): Shortcut through the methylation cycle. Is not important once the long route is fixed. May be related to AD(H)D.
BHTM-08++ (~15%): cfr.
AHCY-01+- (~20): Not much research about it. Possibly higher cysteine levels.
AHCY-19+- (?): cfr.
CBS C699T+- (~50%): Slight CBS upregulation. Lower homocysteine levels and higher glutathione. Beneficial.
CBS A360A+- (?): Lack of research.
So, there isn’t a single polymorphism that can cause any problems. I guess the treatment of Yasko relies on a lot of try and error and she probably uses genetics to back up her treatment with some sort of theoretical base which may or may not make sense.
Something else I found out.
Remember in the first post, I was talking about a feeling that could be described as ‘burning brain’. I’m starting to become convinced that this may be inflammation. The reason why I believe I’m dealing with inflammation is because I tried two anti-inflammatories recomended by Hip[/url] with varying results. This problem is actually the most limiting issue. Other stuff that help with this problem is Magtein (Magnesium that crosses the BBB).
I have great success with N-Acetyl Glucosamine (NAG), but I have to take much higher doses than what he takes. It also loses potential after a while. I’ve also tried flax seed oil, but not consistent enough to be able to conclude anything. I had a terrible experience with turmeric, which I had high hopes for. I really think it has great potential, but I can’t use it for now for some reason. The effect of turmeric were similar of that of N-Acetyl Cysteine (NAC). NAC almost nocked me out. You can read about it here[/url].
Either way, whatever I do is mostly irrelevant if I haven’t slept enough. Now that I’m working and can’t sleep than I’m used to, this problem has become really apparent.
I have no idea what causes this burning sensation/inflammation. It is possible that glutathione levels are low? Maybe it’s a cortisol problem (it subsides during the evening) or glutamate overload. I don’t think pyrrole disorder can cause these levels of inflammation.
This problem is somewhat correlated with trembling/other neurological problems. If they get worse, inflammation gets worse. One thing that is really odd is the fact that this pain can move around. Usually it’s on the left side of my head, sometimes right behind my eyes, other times it’s everywhere or more to the side of my neck.
There are certain things that aggravate this. Bright light, loud noises, large groups of people, reading articles/books, stress. In practice, this means things like supermarkets, stores, studying, cinema, …
I also think inflammation is the cause of the numerous headaches I had as a child.
There are things that I cannot explain at this moment:
Random neurological pain. It can occur in my back, knees, thumbs.
Joint pain that moves around. Used to be in my right knee for some time, right shoulder, but mostly in my fingers.
Itching left shoulder.
Pins and needles on my back, chest and head (only after exercise).
Balance problems which occur at random.
These symptoms occur mostly together.
Other rare things that happen:
‘Double vision’ in my right eye. It is very difficult to read anything with it, even with glasses and big font. It looks like words are moving and I don’t have complete vision. I have a -2 correction, which isn’t that big. I’ve recently noticed that I have a layer of static noise on top of my vision. It’s called Visual Snow, but it’s very minor and I don’t notice unless I focus on it.
I also have some eye floaters.
Something that is very weird: sort of ‘pulsating’ that can occur everywhere, usually in my arms. I hope I can record this sometime.
Doing a urine test for pyrrole disorder is probably not all that useful for multiple reasons. Foremost, I’ve been taken large amounts of B6 and zinc. And now that I’m no longer studying but working, stress levels are greatly reduced.
I’ve ordered a urine test anyway, but I expect it to be negative. For now, I’ve ceased all supplements. By the time I do the urine test, it would be 2.5 weeks without them.
Meanwhile at the office without supplements and a lack of sleep. What you see here is what I have all the time, internal tremors. But now they are clearly visible.
Edit: I’ve done the urine test (from Keac in The Netherlands). Not under uptimal conditions. There was a bit of light coming the the room. I don’t have fluorescent lights. But I did use aluminium foil. I’ve sent the package through the post. Unfortunately, the people at the post office didn’t understand “as fast as possible”, so it was 6 days on it’s way. Uncooled!
There are two reasons for the test to be negative. The amount of supplements I took before doing the test. The lab states that: “Your result can be false negative if you recently took vitamins and minerals on a regular basis. The amount of excreted HPL decreases gradually and will in the short period that you are not using supplements, right before the test, go up a little, but maybe inadequate to get a positive result. In general you can assume that the test will be negative if you’ve taken more than 100 mg B6 for a long period of time.”.
Second reason is the time between collection and testing. According to Applied Analytical Laboratories:
HPL is very reactive and decomposes as soon as it leaves the body. It has a half-life of 10-12 hours (which means that if not frozen, after the first 24 hours, the level of HPL in the sample will be approximately 20% of the original value and 5% of the original value after 48 hours – which is also dependent on ambient temperature and other factors). In terms of results, this property results in enormous variability (which is not desirable for a reliable diagnostic test). In early development work on urinary pyrrole test in Australia by this author, it was also found that the exposure of samples to direct sunlight (or collection in a room illuminated by direct sunlight) resulted in almost instantaneous elimination of all HPL activity. In almost all cases in this laboratory, no detectable HPL has been found in samples that have thawed during transit (or arrived unfrozen).
I was highly surprised that the test came back as ‘lightly positive’ which makes me wonder what the real result is. The actual number is 0.625 (they use umol/l). According to the half-life counting, it would be 2^12 = 4096 time higer which is kind of impossible. So the half life rule is probably something that only works initially.
This result is in line with the hair test and confirms what I already knew. Now I know a bit more.
Pyrrole disorder is an indicator that there is something wrong and it is an important marker for oxidative stress and inflammation.
The question I have is what the real value of this test actually was. And more importantly, whether lyme is involved in all this. If that’s the case, it would change the whole story.
The lab advices maximum 30 mg of zinc and 50 mg of p5p per day, which are very low doses.
I’ve been taken 3×250 mg B6, 100-150 mg zinc picolinate and 50 mg p5p per day. Especially the high B6 levels are really beneficial. It will take some time to understand what the implications are long term, but so far they are good. All white zinc spots on my fingers are gone. I have less cold hands and feet. Candida die off is waaaaay down. Neurological pain and muscle pain also lower.
I may need to go as high as 2000 mg B6 / day. That’s 1000x the daily recommended dose 🙂 100 mg zinc is probably still too low. But taking high amounts of zinc can knock off copper levels.
Spoken about lyme, there are a lot of blogs of people who are dealing with lyme. They contain a tremendous amount of helpful information. Especially when it comes to fighting inflammation. Coincidentially, I found a blog[/url] of someone who has done a hair test that has a striking resemblance with my own hair test. The symptoms she had/has (halfway through the page) are mostly similar as well. She got better through chelation only.
I always had the idea that people with lyme are bedridden, but this isn’t the case in most situations.
Some other video that I stumbled upon from someone who is dealing with lyme:
Listen to what he says from 10m40s to 13m00s.
There are other symptoms that are interesting, especially this one:
Short term memory loss in those with Lyme Disease usually plays out in a manner similar to this: Thinking of something to say, waiting for the person being spoken to to finish their statement, knowing that you’ll be able to recall it in a few seconds, and then when those few seconds are up, being completely unable to find or recall that idea or what you wanted to say. This can be very embarrassing. This cognitive dysfunction can include just finding the right word for expression, or if they’re really brazen, telling entire idea or story.
In the meantime, I’ve made an appointment with a (ILADS) lyme and ME/CFS specialist, to figure out if there is a possibility of having lyme and also to figure out other stuff. Things are becoming kind of complicated. Someone on this forum made a post[/url] about him. I still have to read it.
Lyme tests tend to be very inaccurate and have a high rate of false negatives. I heard the IGeneX lab has the most accurate test?
I hope next post, I’ll be able to post some lab results.April 17, 2016 at 9:30 am #172384
alexisMCAParticipantTopics: 15Replies: 33
Wow you have been through hell and back like many of us have but what I am reading is so impressive because you are researching and charting your course and understanding.
I am struggling on day 17 of the anti-candida diet and started from an acute phase where everything was blown up by it and learning so much.
It is maddening a lot of this because there are so many subtleties that one has to learn in error and the error is die-off symptoms and hell!
You mention turmeric as you wrote about could be a trigger for something. I use it everyday in my green morning drink. I believed it was helpful for me and overall but perhaps you can share what you notice specific from turmeric to help me identify if it may be a trigger for something I am experiencing that I believe is die-off that is not.
Thank you for sharing!
AlexisApril 17, 2016 at 12:54 pm #172388
What I experience from turmeric isn’t die off. It’s something else. It feels like it is irritating my nerves. I don’t know how else to explain it. Maybe it is inflammatory related.April 17, 2016 at 1:02 pm #172389
alexisMCAParticipantTopics: 15Replies: 33
Thank you for sharing!December 6, 2016 at 4:37 pm #173487
Note: I’ve found the root cause of the problem, which means that this is probably my last post on this forum. You can always find me on PhoenixRising under the same username.
Some of the formatting is also messed up. For better formatting: see my phoenixrising post.
It’s been a while since I got all the results. Figuring everything out and writing it all down took some time, hence the delay. I also wasn’t really overjoyed in starting to write either.
During the first appointment at Himmunitas, you have to fill in a list with symptoms.
Dr Richard Horowitz has a similar questionnaire that specifically assesses Lyme. I got a score of 45 when I filled in his list which implies a high probability of a tick-borne infection.
Himmunitas is led by Dr. Kenny De Meirleir (KDM) who is a professor at Vrije Universiteit Brussel. People from whole Europe come to Belgium to visit him.
KDM quickly goes over the list.
“I know what’s going on.” he said. “Please lay down.”
He pushed on my lower abdomen which hurt a lot. “The connection between your small and large intestine is inflamed. The good news is that this is easy to fix.”
KDM doesn’t really says much but he asks very specific questions.
How long has this been going on? What is your profession? Where do you live? Do you have any fillings? Do you have any pets? Do you take any medications?
A few minutes later he already wrapped up.
“I’m sure this is Lyme. But we’ll wait for the test results. Soon, you’ll receive a list of tests that we will run.”
It felt like I was only 10 minutes in his office.
KDM has a reputation to call everything Lyme. I wanted proof, black on white.
One day later, I received an email with all the tests and price (in Euro).
Mold antibodies 41.72
Pro-inflammatory Cytokines 164
CD57 absolute count 62
PGE2 Elisa 70
VEGF Elisa 70
Kynurenic acid 100
BABESIA FISH 140
DNA extraction 50
Bartonella PCR 99
Borrelia elispot LTT 234.49
Bartonella Al 28
1.25 di OH VitD 7
Food allergy test 160
Urine test 130
Total cost: 2332.21 euro. Because Himmunitas is a private institution, none of this is refunded.
I guess KDM knows what he is doing so I just approved this list.
A few weeks later I had to do a lactose test. Two days later a fructose test together with the above blood tests.
The lactose and fructose test measure if you’re breathing out hydrogen. If so, this means that you’re missing an enzyme to process lactose/fructose. Doing this test requires measurements every 30 minutes. It takes a few hours in total.
During the blood test, about 10 vials are collected (still not all that much considering the amount of tests). The tests are sent to various labs around the world.
The MSA test is a stool test which you have to collect yourself, like the urine test.
Before blood is collected, the assistant goes over all the tests that will be ordered. You have to sign these documents so they can legally requests payment. During this whole time you don’t visit KDM.
It takes about 2 months before the blood results are in. (For me tests were done in May and the results were available in July.)
This is when you visit KDM again.
Beforehand, I had to do a bike test to test heart and oxygen intake capacity. This test takes about 20 minutes and requires increasing effort. The experiment is very simple. Just keep on cycling until you can’t keep up with a certain difficulty anymore.
Afterwards you return to the waiting room and wait until the professor calls you in.
KDM: “You’ve gone through an active Lyme infection. This has changed the flora of your bowels. You have SIBO – small intestine bacterial overgrowth. 50% of your bacteria are anaerobic, while it should only be 10%. This probably explains your high ammonia levels, which is twice as high as it should be. You are constantly poisoning yourself from the inside out.”
“We’ve also detected some food allergies, but those are only secondary.”
– “Have you detected any coinfections?”
“No coinfections were found with our tests. I’m not going to hunt them right now.”
“It makes no sense to start antibiotics against Lyme at this point. We’re going to fix your intestines first. This is done through phytotherapy. As long as Lyme stays at bay, this shouldn’t be too hard. I hope that I can send you your report today, but my assistants are complaining that they have to work 2 hours more today. You can’t work in this country anymore.”
He concluded with “No worries. You’re gonna be alright.”
Another very short encounter.
Turns out my suspicion was right. Finally I’ve found someone that could actually help me.
On Monday (instead of Friday), I received my report. It consisted of 26 pages worth of test results. The prescriptions and supplement list were added, including some directions and a food diet. KDM didn’t mention anything about this. I guess you just have to follow the instructions on paper.
The results below can be kind of technical. The lab results are in red.
Reference ranges are between  as usual.
Summary and conclusion
Leucocyte formula: low amount of monocytes
Serum ammonia: elevated
Borrelia burgdorferi Elispot LTT: positive
Panel IgG for various fungi: negative
Panel IgM/IgG en PCR for various zoonoses: negative
Immunophenotyping: normal distribution of lymphocyte subsets
CD57+ lymphocytes: low in numbers
Kynurenic acid: normal
Soluble CD14: elevated
Cytokines in serum: IL-8 elevated
Yersinia and Chlamydiae serology: negative
Urine neurotoxin test: positive (3+)
FOODStats: some food intolerances
Fesces investigation: high sIgA / normal – negative
Fecal microbial analysis: high % Clostridium sensu strictu, Bacteroides, Odoribacter and Clostridium IV/XI; low % Bifidobacterium
The history, the progress of the disease, complaints and the results of the laboratorium investigation of this patient belong to Post-Lyme disease.
There is a Th1 -> Th2 switch present (UNT test positive) and the amount of CD57+ lymphocytes is relatively low in numbers.
There are some food intolerances (secundary).
He shows an intestinal dysbiosis with overgrowth of anaerobics (explains why serum ammonia is elevated).
The elevated sCD14 points to increased transfection of gramnegative bacteria.
See later for an explanation of the summary.
Elispot LTT – Arminlabs (Lab in Germany)
Borrelia burgdorferi Elispot
Borrelia burgdorferi Full Antigen 3 SI [< 2]
Borrelia b.OSP-Mix (OSPA/OSPC/DbpA) 1 SI [< 2]
Borrelia burgdorferi LFA-1 0 SI [< 2]
The result of the Elispot-Tests are an indication for a current cellular activity against Borrelia burgdorferi.
Explanation of antigens:
– Borrelia burgdorferi Full Antigen: Borrelia b. B31-reference strain (Borrelia b sensu stricto)
– Borrelia burgdorferi Peptide-Mix: OspA from Borrelia b. sensu stricto, Borrelia afzelii, Borrelia garinii + OspC native + DbpA recombinant
– Borrelia burgdorferi LFA-1 (Lymphocyte Function Antigen 1): Own body protein + Borrelia burgdorferi sensu stricto (shared epitope). Often associated with autoimmune diseases, collagenosis, Rheumatoid Arthritis, vasculitis. If positive or borderline positive look at ANA, CCP-antibodies, ANCA.
CD57 – RED Laboratories
CD57 Absolute count 55 [60-360 cells/mcl]
Borrelia burgdorferi is the bacterium that causes Lyme disease. It was first discovered by Willy Burgdorfer in 1982 after the emergence of a mysterious disease that caused arthritis in Connecticut, Lyme. It was first tought to be a member of the syphilis family because the bacteria looked very familiar.
Lyme disease is primarily transmitted by the bite of a tick. Because it is a spirochite, the bacteria can drill itself rapidly through tissues. It can reach the heart, central nervous system, bone marrow and brain within a matter of days after the initial infection.
The official guideline for diagnosing Lyme is both a positive Elisa and a positive Western Blot. The problem with those tests is that they are highly unreliable. Some refer to these tests as doing a coin toss (because of their ~50% accuracy). Both tests rely on the presense of antibodies against the Lyme bacteria which are not always present. The immune system only starts making antibodies after a few weeks. Furthermore, Borrelia can hide itself from the immune system causing a lot of blood tests to come back negative. Patients with a positive blood test are the minority and should actually be considered ‘lucky’.
For the Western Blot test, specific antibodies are measured. Odly enough, certain specific antibodies for Lyme are often not included in the offcial guidelines, which makes the accuracy of the test even worse.
The CDC (Centers for Disease Control) estimates that the total amount of Lyme desease cases is 10 times higher than the current detection rate. It even admits that the Western Blot shouldn’t be used as a diagnostic tool, but it is still used by most physicians.
The CDC now notes that while there are around 30000 reported cases of Lyme, the true incidence is at least ten times that – some 300000 new infections each year. A CDC release (August 19, 2013) commented that “this new estimate supports studies published in the 1990s indicating that the true number of cases is between 3- and 12-fold higher than the number of reported cases.”
The CDC knew for decades that Lyme was greatly underreported, but kept it a secret.
According to CDC-posted statistics, the number of people diagnosed with LD is now 1.5 times greater than the number of women diagnosed with breast cancer and 6 times greater than the number of people diagnosed with HIV/AIDS.
If Lyme is not treated early on, chances are increasing that it will spread to areas where the immune system is not effective or where antibiotics can’t reach. For example the bone marrow or the heart, but an excellent example of such a safe spot is the brain. It also has the ability to hide itselfs from the immune system by transforming to a cyst form or surround itself by protective biofilms.
Because Lyme disease settles itself in the brain and the central nervous system, it is known to cause neuropsychiatric disorders. For example trembling, dizziness, imbalance, word finding problems, anxiety, depression, brain fog, light and sound sensitivity, poor motor skills, headaches/migraines, dementia, neuropathy, …
Lyme disease can mimic any symptom and any disease. Because so many symptoms can occur, it is sometimes hard to get the diagnosis of Lyme disease. For example, it can mimic the symptoms of Heart Disease[/url].
The most important marker for Lyme disease is pain that comes and goes, with good and bad days. Usually there are a multitude of symptoms present that are completely unrelated. The bad days are usually caused by toxins that get released when the spirochetes get killed by the immune system.
A lot of times psychiatric symptoms are present in combination with a variety of other symptoms, which increases the chance of concluding that it’s all in the patients head.
In the past, Lyme infections in the central nervous system and brain have been routinely misdiagnosed as multiple sclerosis, Parkinson’s disease, Alzheimer’s disease (AD), as well as a wide range of psychiatric conditions from bipolar to schizophrenia. The root causes of these conditions have never been known, though there’s been a lot of guessing going on.
In the first edition of this book, I noted that some autopsies of Alzheimer’s patients had found spirochetes in the brain tissue. […] The best work on the connection between Borrelia and AD has been done by Judith Miklossy, beginning with her PhD thesis in 2005. […] The results show a statistically significant association between spirochetes and AD. When neutral techniques recognizing all types of spirochets were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls.
Late/chronic Lyme neuroborreliosis is characterized by various neuropsychiatric manifestations, including mood disorders, psychosis, schizophrenia, visual and auditory hallucinations, paranoia, anorexia nervosa, and obsessive-compulsive disorder (OCD).
Pathologist Alan MacDonald found that 7 out of 10 brains with Alzheimers disease turned out to have the borrelia spirochete. Btw, he almost has his new research funded.
Because the immune system that is active in the brain is not very good at recognizing infections, it is very hard to know whether it is active in the brain with a regular blood test.
The toxins that are released by Lyme, but also the inflammation, causes encephalitis (swelling of the brain) and makes the brain more sensitive to external stimulation. This is the main cause of – sometimes extreme – anxiety in Lyme patients. Some suspect Lyme to kill serotonin receptors, which is exactly the opposite of what most antidepressants (SSRIs) do. What is known is that Lyme decreases tryptophan (precursor of serotonin). Both interventions make Lyme patients highly apathic.
Serotonin is often referred to as the neurotransmitter that causes feelings of well-being. But it has more functions, it acts as a general messenger to improve memory, cognition, sleep and appetite.
[…] They lack nearly 100% of the time any interest, concern, and emotion for life’s experience.
A possible defense mechanism initiated by the brain to allow a person to continuously be subjected to what would otherwise be extreme conditions and circumstances for sustaining life. And that the depersonalizing of the person will give them an upper hand in enduring a continuously extreme and stressful environment, but at the same time achieving the brain’s intended goal of perpetuating survival.
The emotions involved in the experience of enduring a chronic illness and everything that it encompasses can be too extreme for the mind. By forfeiting, halting, and suspending its ability to generate emotions, the part of the brain responsible for rationality and reasoning can function without being compromised by extreme emotions. And by allowing the part of the brain that reasons to operate without interference by emotions, a person will greatly increase their odds of obtaining solutions for their troubling state and debilitating circumstances of Lyme.
Of course this depends on how sick the person in question is. Some argue that depseronalization is caused directly by toxins released by Lyme.
As time progresses, chronic conditions arise, most commenly radiculoneuropathy (constant inflammation of the nerve roots causing pain and loss of function to verying degrees in the parts of the body that those nerves serve), encephalopathy (brain inflammation) accompanied by impairment of various cognitive processes including memory loss, and leukoencephalitis (ie brain inflammation caused by the movement of neurotoxic leukocytess into the brain). Infected regions of the brain begin to degrade, leading to area-specific functional damage.
[…] Encephalopathy is often accompanied by memory problems and depression. Sleepiness in the daytime and wakefulness at night are common. Extreme irritability, fatigue, headaches, disorganization and conntinual mild incoherence occur as well. Nerve pain is often present.
Medical testing continually finds measurable deficits in: memory, new learning, retrieval of information, attention and concentration, perceptiul motor skills and problem solving. (In other words, while the infection is in their heads, it’s not all in their heads.)
Despite most people’s strenuous efforts to overcome these deficits, they are generally unsuccessful in doing so; the spirochete infection of the CNS has too many impacts on cognition. Children tend to have significantly fewer cognitive problems (eg, memory and thinking) than adults – most likely because the older we become, the less vital our neurological structures and immune function are. In adults, the ability to think and solve problems can be severe.
A second impairment to clear thinking that Lymies experience is the restriction of proper circulation within the blood vessels inside the brain. Using an instrument called the Single Photon Emission Computer Tomography scanner (SPECT scans), we are able to visualize the blood flow throughout the human brain in 3D detail. What was seen in the brains of chronic neurological Lyme patients was an abnormal “swiss-cheese” pattern of blood flow. The cortical, or thinking region of the brain, was being deprived of good circulation; the occipital (eyesight) regions had an increase flow. This could help explain why most Lyme patients complain of poor concentration and overly sensitive eyes.
Because of the unreliable tests that depend on a very weak – sometimes nonexistent – immune response, because Lyme can alter their genetic makeup and because there are so many different species of the bacteria, Lyme should be diagnosed based on symptoms alone. Lab tests are just done to confirm the clinical diagnosis.
Patients whose immune system is completely compromised are more sick, but are less likely to deliver a positive blood test due to the lack of antibodies.
In 2008 a documentary was made about Lyme disease. The patients presented in this documentary shows how much this disease can vary.
The division time of Borrelia burgdorferi is very long. Most other pathogens such as Streptococcus, or Staphylococcus, only take 20 minutes to double, the doubling time of Borrelia burgdorferi is usually estimated to be 12-24 hours. Since most antibiotics are cell wall agent inhibitors, they can only kill bacteria when the bacteria begins to divide and form new cell wall.
This means: Since most antibiotics can only kill bacteria when they are dividing, a slow doubling time means less lethal exposure to antibiotics. Most bacteria are killed in 10-14 days of antibiotic. To get the same amount of lethal exposure during new cell wall formation of a Lyme spirochete, the antibiotic would have to be present 24 hours a day for 1 year and six months! […]
Like other spirochetes, such as those that cause syphilis, the Lyme spirochete can remain in the human body for years in a non-metabolic state. It is essentially in suspended animation, and since it does not metabolize in this state, antibiotics are not absorbed or effective. When the conditions are right, those bacteria that survive, can seed back into the blood stream and initiate a relapse.
The most intriguing fact about Borrelia spirochetes is their well documented ability to change the shape of their surface antigens when they are attacked by the human immune system. When this occurs, it takes several weeks for the immune system to produce new antibodies. During this time the infection continues to divide and hide.
This means: Infections of the bloodstream may be different from the infections that are sequestered in the brain. While we continue to have active immunity in the bloodstream, the brain has no immune defenses except for circulating antibodies. So, if those circulating antibodies are ineffective to attack the bacteria in the brain, then the brain is left without any defenses, and the infection goes unabated.
Besides the cyst form and the use of biofilms, Lyme bacteria can change their outer-cell-wall proteins which disguises the bacteria. The immune system continues its attack without being able to identify the invador. This causes inflammation and damages tissues everywhere.
Lyme disease didn’t get quite known until recently. In Avril Lavigne was diagnosed with Lyme disease. She was lucky to catch it early on.
John Caudwell (English billionaire) was diagnosed with a chronic case.
The case of Ally Hilfiger is very interesting because she was also infected in her childhood.
Other two good explanations: 1 and 2
A lot of people with Lyme disease don’t really look sick, but can feel really sick from an infection that is potentially life threatening.
On average, people with chronic Lyme are thought to have a worse quality of life than people with congestive heart failure.
A lot of tics don’t only carry the borrelia spirochete, but also a bunch of coinfections like bartonella, babesia, chlamichdia which all have their own symptoms. People with coinfections tend to be sicker (this is also true for people who have mercury poisoning). Tests for coinfections are usually even less reliable than the Lyme tests.
Back to the results.
As far as I understand, the Elispot LTT measures antibody production of T helper cells against Borrelia Burgdorferi (and other Borrelia cultures). T helper cells are part of the adaptive immune response. Its job is to identify pathogens and inform other parts of the immune system about this pathogen by making cytokines. In HIV, these are the cells that get destroyed.
Because T helper cells have a half life of a few weeks, it measures recent exposure to Borrelia.
According to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474945/, the sensitivity of the LTT in clinical borreliosis before antibiotic treatment was determined as 89.4% while the specificity was 98.7%. In other words 10.6% false positives and 1.3% false negatives. So this test performs extremely well compared to other tests.
My test is positive, even just slightly. So there is still a 10.6% chance that it isn’t Lyme (according to this test alone).
‘Sensu stricto’ means ‘in the strict sense’. It refers to Borrelia Burgdorferi itself. ‘Sensu lato’ would mean all Borrelia species that cause Lyme-like disease. The test was positive for Borrelia Burgdorferi which is most widespread in the US. In Europe, Borrelia Afzelii and Borrelia Garinii are much more common.
The most important thing to understand about Lyme disease is that the bacteria have an affinity for collagenous tissues. This is at the root of every symptom thay cause.
Borrelial bacteria are parasites. They cannot make very many of the substances they need to live, so they harvest them from their hosts. As Margulis et al. (2009) comment, “Human tissue provides food and other conditions of growth for… Borrelia burgdorferi spirochetes.” The majority of the food they need is to be found in collagen-like tissues throughout the body. Wherever they feed on those tissues is where the symptoms occur. If they find them in the joints, it’s arthritis. If they find them in the skin, various skin manifestations emerge. If in the heart, heart disease. If in the nervous systemor the brain, neurological symptoms.
For example, the nerves in our brains are covered by myelin sheaths, much like electrical wires are covered by thin plastic insulation sheaths. As with electrical wire, this keeps the nerves protected, insulated. Once borrelial bacteria attach to those sheaths, they use a variety of substances to break them down into a kind of soup of nutrients from which they feed. Once demyelinated, the nerves begin to produce aberrations in the nervous system function. This is at the root of most of the neurological symptoms the bacteria cause.
The CD57 count represent a specific Natural Killer cell or NK cell which is a subset of T lymphocytes which are responsible for killing foreign invadors. The CD57 cell is uniquely attracted to Borrelia Burgdorferi. For some reason Lyme is able to reduce CD57 cells.
It can also be used to track the progression of the treatment. The general rule is that a lower CD57 count means a more progressive case of Lyme. In general, because this rule is absolutely not 100% reliable. The count can increase because of certain infections or auto-immune disorders which sometimes coexist with Lyme. It can be used as a complementary lab test.
HIV patients have a similar test they can perform, but in their case the CD4 count is low.
Normal levels are around 200. Beneath 100 are highly suspicious. Less than 60 is considered as having ‘Chronic Lyme Disease’. Less than 20 indicates ‘Severe Illness’.
A CD57 count of 55 (the red line) is just a confirmation of a chronic Lyme diagnosis. Anything below 100 is a strong indication of a chronic Lyme infection.
Everything else is just the consequence of the Lyme infection.
Ammonia in serum 6.08 [0.28-3.03]
Urea 41.7 mg/dl [17-43]
Uric Acid 6.3 mg/dl [3.4-7]
Ammonia levels are twice the maximum levels.
High levels of ammonia are toxic and a liver burden. Long exposure to ammonia might be the reason for the liver pain I had.
Ammonia stimulates the NMDA receptors. NMDA overstimulation agitates brian cells, causes anxiety and can even cause brain cell death. NMDA overstimulation is related to multiple chemical sensitivities.
Very high levels of ammonia can be dangerous.
The cause of high ammonia can be a liver problem. Ammonia is converted into uric acid and urea by the liver and excreted by the kidneys. Since both urea and uric acid are high, it is probably not a liver problem.
According to KDM, high ammonia is caused by the bacterial overgrowth which is constantly producing ammonia as a waste product.
Lyme itself can also cause high ammonia levels.
IL-10 serum 2 pg/ml [0-5]
IL-122p70 serum 0 pg/ml [0-5]
IL-1beta serum 1 pg/ml [0-3]
IL-6 serum 3 pg/ml [0-5]
IL-8 serum 479 pg/ml [0-15]
MCP1 121 pg/ml [0-165]
MIP-1BETA serum 120 pg/ml [0-155]
Activated TGF-BETA1 serum 5364 pg/ml [1674-12400]
TNF serum 0 pg/ml [0-6]
They are all within limits, except for IL-8. IL-8 is an inflammatory cytokine. Cytokines are proteins that are among others responsible for a propper immune system response. They modulate the balance between humoral and cell-based immune responses. (see later)
Cytokines are the main reason why people feel sick when they are ill.
Inflammatory cytokines can pass through the Blood Brain Barrier and cause inflammation of the central nervous system.
IL-8 is an important neutrophil activator.
Neutrophils orchestrate an extremely complex response to microbial pathogens. Among them is the recently discovered capacity to create neutrophil extracellular traps or NETs for trapping and killing microbes.
NETs are formed by neutrophils on contact with many microbes (including a large variety of protozoa), as well as activated platelets, and a number of inflammatory stimuli. Once stimulated in this way, a major alteration in the structure of the neutrophil cells occur. The cells begin to unwind and then extrude their DNA as well as histones (and a few other substances) to form a kind of net or spiderweb or cage that traps pathogens within it. In essence, the DNA is unspooled and used, along with the histones, to create a web work to entrap pathogens. NETs are able to trap nearly all types of pathogens, including those too large to phagocytose, among them Gram-negative and -positive bacteria, viruses, protozoa and yeasts.
A vital immune system enhances the ability of neutrophils to form NETs, ultimately clearing the Borrelia, no matter the form, from the body.
Neutrophils can become neurotoxic which increases the release of certain activated immune cells. Those can enter the brain and cause neuron death.
SCD14 3999 ng/ml [1430-2800]
CD14 is expressed in monocytes/macrophages and has a critical role in the recognition of bacterial cell wall components (LPS). The extracellular part of CD14 can be cleaved and released in the plasma. There it will inactivate circulating LPS. Serum soluble CD14 levels are significantly elevated in patients with inflammatory bowel disease and Crohn’s disease. In patients suffering from Brucellosis or Lyme disease these levels are significantly elevated too.
High sCD14 suggests leaky gut.
sIgA 6413 mcg/ml [510-2040]
Immunoglobulin A is an antibody that is located in the mucous and is part of the intestinal immune defense. sIgA binds to micro organisms and toxins in the bowel system.
High sIgA levels usually indicate an immune overreaction and point towards a high degree of food sensitivities and intolerances.
An increased level of sIgA shows intestinal inflammation.
Urine neurotoxinetest: positive (3+)
There is a Th1 -> Th2 switch present.
Two things were tested through the urine test. The presense of neurotoxins and a Th1/Th2 imbalance.
There was no testsheet included in the report because it was executed locally, even though it is explained on their website. The test is either positive or negative. Maybe other tests are being done. But in my case, those two were positive.
The presense of neurotoxins is to be expected in Lyme.
I’ve asked KDM about the meaning of a Th1/Th2 ‘switch’. It’s means that there is an imbalance between cellular (Th1) and humoral (Th2) immunity in favor of the humoral (Th2) immunity. This is typical for chronic Lyme patients.
One of the primary strategies of the Lyme-group of microbes is their ability to shift human immune responses from a Th1 dynamic to Th2. T helper cells (abbreviated Th) are a specific form of T cell. T cells are white blood cells that become active during certain kinds of infections; there are a number of different kinds, among them T helper cells. Th cells, well, they help other white blood cells do their job. […] Once stimulated, Th cells rapidly reproduce and help deal with infections. Th1 cells usually stimuate high inflammatory, very active cytokines. There are, of course, a number of different kinds of Th cells, not just Th1 and Th2. There’s Th3, and Th9 and Th17, and so on. Each subgroup has evolved to deal with different kinds of infections.
[…] Th1 cells are specific for intracellular infections; that is, infections from microbes that hide inside other cells (as most of the Lyme-group do). It’s not surprising then that, long ago, most of this bacterial group learned to subvert Th1 responses, shifting them to a mostly Th2 dynamic. (Th2 responses are normally intended to deal with intestinal parasites such as nematodes; they also are specific for reducing upregulated and overactive Th1 responses.) The shift from Th1 to Th2 facilitates infection by the Lyme-group of stealth pathogens and strongly inhibits an effective immune response. A polarized Th2 response is also common in many autoimmune diseases such as lupus and systemic sclerosis. This is part of why so many of the Lyme-group infections appear to be and autoimmmune disorder.
[…] Unsurprisingly, each Th group initiates different cytokine profiles. Th1 cells tend to generate IFN-gamma, IL-12 and INF-a; Th2 tends to produce IL-4, IL-5, IL-10 and IL-13. Inhibiting IL-10 can force the infection away from the Th2 dynamic and back into Th1, which is necessary for the immune system to be able to clear the infection.
[…] many stealth pathogens (such as Borrelia) carefully modulate the entire cytokine profile and Th1/Th2 dynamic. This makes the immune response ineffective allowing continued spirochete feeding and reproduction.
[…] As Jarefors et al. (2006) comment: “We have found that the spontaneous cytokine secretion in patient with a history of chronic LB is Th2-dominated.”
[…] Suppression of Th2 dynamics have been found to lower spirochete load.
[…] During the very early stages of Lyme infection, the body upregulates IFN-gamma, a very potent Th1 cytokine. But during many Lyme infections, the bacteria counter it fairly quickly. As Binder et al (2012) note…
IL-10 upregulation is part of how they accomplish the downregulation of IFN-Gamma and other Th1 responses. By keeping IL-10 high, they keep a long-term, chronic infection ongoing.
[…] Remodulating (or descreasing) the IL-10 and Th2 response will reduce many of the Lyme symptoms and help eliminate the organisms from the body.
So, Lyme can make the immune system ineffective by shifting the immune response using cytokines. Shifting the immune response in the correct direction seems to be crucial.
According to KDM, almost all his patients that are seriously ill have this Th1/Th2 switch.
Metagenomics Stool Analysis (Red Labs)
This test checks what bacterial colonies are present in your bowels.
It makes no sense to go over all the results. The ones that are out of range:
Ruminococcus 0.07 [>2]
Clostridium Sensu Stric. 7.16 [<5]
Eubacterium 0.04 
Bacteroides 18.43 [<10]
Odoribacter 1.12 [<0.5]
Bifidobacterum 2.96 [>5]
Rothia 0.33 [<0.2]
Asaccharobacter 0 [>0.1]
Low ratio may be associated with gut inflammation
Diversity Index 4.31
Low <4, Average 4-5, High >5
Dysbiosis associated with low diversity
Fecal microbial analysis: high % Clostridium sensu strictu, Bacteroides, Odoribacter and Clostridium IV/XI; low % Bifidobacterium
The high levels of Bacteroides causes the low ratio and indicates gut inflammation.
The low Gram+/Gram- ratio is caused by both high Bacteroides and low Bifidobacterium.
Bottom line, my bowels are very disturbed.
An overgrowth of anaerobic bacteria (especially with a low Firmicutes/Bacteroidetes ratio) causes a malabsorption of calories (partly because they use it themselves). This means that it is impossible at this moment to gain weight.
According to KDM, the surface of a football field worth of bacteria are replaced every day. Lyme has the ability to lower ones ability to reproduce bowel bacteria by about 30%. Over a long time, this can be sufficient to completely destroy the correct culture ratios. This leads to bowel inflammation which causes cytokine production (of course the ones you don’t want) and malabsorption.
Especially B12 is affected by malabsorption. According to Andreas Moritz, a vitamin B12 deficiency is mainly caused by malabsorption not a lack of B12 in the diet. A B12 deficiency can explain higher levels of mean corpuscular volume (MCV) which defines the volume of red blood cells. An MCV value that is out of range indicates anemia. If it’s too low (microlytic anemia) it may indicate an iron deficiency. If it’s too hig (macrolytic anemia) it may indicate a B12 or B9 deficiency.
MCV has always been high but just in range, except for a few times.
Alcohol is also very detrimental to bowel bacteria.
Food Allergy Test
This test was carried out by BioTek in the USSA.
It uses an ELISA (Enzyme-Linked Immunosorbent Assay) test to determine allergic responses. In my case the IgG antibodies were measured.
IgG reactions are delayed reactions, hours to days after ingestion of the allergen.
The results are a bit surprising.
Minor food allergies.
Extremely high allergies for eggs.
Moderate allergies for Kidney and String Beans.
Some allergies for sugar cane.
Fruits, vegetables and fish were negative.
All those food allergies will disappear over time.
White blood cells
Leukocytes 4300 [3650-9300]
– Neutrophilic segments 56.4% [38.9-74.9]
– Eosinophils 0.7% [0.4-5]
– Basophils 0.4% [0.2-1]
– Lymphocytes 39.2% [16.1-46.9]
– Monocytes 3.3% [4.6-12.7]
– Neutrophils 2425/mcl [1573-6100]
– Eosinophils 30/mcl [28-273]
– Basophils 17/mcl [6-50]
– Lymphocytes 1686/mcl [1133-3105]
– Monocytes 142/mcl [307-802]
Monocytes are out of whack. Previously they were too high, now they are too low.
The total white blood count is – again – close to 4000.
Lyme has the ability to infiltrate the bone marrow and distrupt (white) blood cell production. Maybe this is one of the causes.
Normal results, but worth mentioning
Kynurenic acid 1.23 [0.85-1.24]
Lyme stimulates dendritic cells to produce an enzyme that breaks down tryptophan (precursor of serotonin).
L-tryptophan, when degraded, becomes L-kynurenine, which then degrades further into three intermediary compounds. All are highly neuro-active in the brain: 3-hyrdoxykynurenine (3-HK), quinolinic acid (QUIN), and kynurenic acid (KYNA).
High QUIN levels in the brain will cause an overstimulation of neurons, produce excitotoxic lesions, degradation of brain tissue, high levels of reactive excitotoxic lesions, degradation of brain tissu, high levels of reactive oxygen species in the brain, and, sometimes, seizures. The precursor to QUIN, 3-HK, is highly neurodestructive as well, causing cellular disintegration, primarily through the generation of free radicals. Neurons are particularly vulnerable to its actions.
KYNA, on the other hand, is neuroprotective and ameliorates the immpacts of QUIN and 3-HK. Unfortunately, the amount of KYNA depends on healthy neuron function, which, during CNS Lyme infection, is severly inhibited. Compromised cellular energy metabolism (specifically, inhibited mitochondrial function – also common during Lyme infections) will also reduce KYNA levels significantly. (Supporting mitochondrial function is crucially important during Lyme infections.)
The indirect destruction of tryptophan by the Lyme infection causes certain substances to be released of which quinolinic acid attacks brain cells. Kynurenic acid ameliorates the effects of this attack.
I’m confused whether high KYNA levels are good or not because they may indicate high QUIN levels.
I think Wikipedia explains it the easiest way:
High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms.
[…] Kynurenic acid shows neuroprotective properties. Some researchers have posited that the increased levels found in cases of neurological degradation is due to a failed attempt to protect the cells.
This result indicates that something is wrong. It most likely means low serotonin (and melatonin) levels because of tryptophan degradation.
I suspect these levels to decrease over time.
VEGF 0.41 [0.37-1.49]
Lyme biotoxins can disrupt VEGF that make and open capillaries throughout the entire body. These biotoxins undermine VEGF function so your capillaries ability to get oxygen to many types of tissues is impaired. A disrupted VEGF system often leads to profound fatigue and body pains, particularly after exercise or pushing yourself to perform a “full day’s work”.
What I can find about low VEGF can also cause neurodegeneration, whereas high VEGF can be an indicator for Bartonella but low levels doesn’t rule it out.
I expect this level to rise over time.
Ferritin 103 mcg/l [30-400]
Previously: 33 mcg/l
Ferritin is a protein that stores and releases iron. So, ferritin levels are a good indication for iron deficiency. Why my ferritin levels are suddenly normal is a mystery. I haven’t taken any iron supplements.
25-OH-vitamine D 47.2 ng/ml [30-100]
1.25-di-OH-vitamine D3 74.3 ng/l [20-75]
Vitamin D is an important immune system regulator. The active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown to inhibit the development of autoimmune diseases, including inflammatory bowel disease (IBD).
Cholecalciferol is inactive: it is converted to its active form by two hydroxylations: the first in the liver, the second in the kidney, to form calcitriol.
Cholecalciferol is the form that is present in supplements. This form is converted into the 25-OH form and this form is converted into the 1.25-di-OH form (which is the active circulating hormone).
I’m a bit surprised that my 1.25 D3 levels are much higher than my 25 D3 levels. They are almost toxic.
High 1.25 D3 is a good thing and may indicate that I’m good at converting the inactive D3 to the active form, but it can also be stimulated by malabsorption or GI damage.
Connection to the hair test
The infection might weaken the body and its mercury detoxification abilities.
Another possibility is based on the fact that, as part of its life cycle and survival mechanism, the Lyme Disease organism itself accumulates and sequesters mercury. Many researchers have observed that some infective organisms, once established inside the human body, store or use mercury to create a living environment, a niche within the body, inside which the body’s defenses are compromised and weakened due to the presence of this heavy metal. Because mercury is an immunosuppressant, it is feasible that the Lyme Disease spirochete sequesters mercury in the body as a tool for continued survival in the host environment. The spirochete would do this by grabbing onto minuscule amounts of mercury circulating in the body due to regular (small) daily mercury exposure. After time, the Lyme Disease organisms would store up more than just a minuscule amount. Significantly increased body burden of mercury would result.
For some reason Lyme uses toxins and heavy metals like lead and mercury to impair the immune system of the host. A lot of Lyme patients will test positive for mercury poisoning. This makes diagnosis even more difficult, because symptoms from mercury poisoning and Lyme disease are almost identical.
Regardless of how it happens, mercury toxicity often accompanies chronic Lyme Disease, so many Lyme Disease sufferers must undertake mercury detoxification. Most people who have Lyme Disease complicated by mercury toxicity do not experience significant improvement in their Lyme symptoms until the mercury is removed.
Mercury symptoms can be very similar to Lyme Disease symptoms. Because the Lyme Disease bacteria and mercury typically occupy the same places in the body, the symptoms of each are very difficult to distinguish. Someone with Lyme Disease may not be aware that they have mercury poisoning and thus assume that all of their symptoms are Lyme Disease-related, when in reality, some are mercury symptoms. A person who knows they have both mercury toxicity and Lyme Disease finds that the next challenge is to separate the symptoms and determine which are caused by which problem.
The confusion is compounded by the fact that as mercury chelators mobilize mercury, the Lyme Disease organism reacts. The presence of mercury in the living environment of the bacteria is advantageous to the bacteria. As the mercury-rich environment is altered, the infection responds with self-protective activities. This means that anyone undertaking chelation treatments will not only experience the symptoms and side effects of mercury mobilization and removal, they will also experience the effects of altered Lyme Disease symptoms.
To make matters even more complicated, when Lyme Disease organisms are being killed or attacked, mercury symptoms may be altered as well. As you manipulate the Lyme bacteria’s living environment and kill Lyme Disease organisms, mercury is mobilized and released. Sometimes mercury is actually stored inside a spirochete or bacterial colony itself.
When that colony is disrupted or eradicated (with antibiotics or rife machines or some other anti-Lyme treatment), mercury is released. This results in an outbreak of both herx reaction symptoms and mercury mobilization symptoms. In fact, many herx symptoms commonly experienced by Lyme Disease sufferers are actually symptoms of mercury mobilization. Because dying Lyme Disease organisms can release mercury, it is important to use a mercury detoxification protocol while undertaking anti-Lyme therapy to sop up the mercury that is released during the killing of Lyme Disease bacteria.
Mercury is a very strong immunosuppressant, and its presence in the body may mask inflammatory Lyme Disease symptoms. Lyme Disease patients may actually feel that their Lyme Disease symptoms are better when they are mercury-poisoned because the inflammatory response to Lyme Disease is reduced. When mercury is removed from the body, an individual may experience increased Lyme Disease symptoms and herx reactions because the immune system has begun to function properly again.
As a final point before closing this mercury discussion, it should be noted that mercury chelators are not able to reach mercury stored inside Lyme Disease organisms until the organisms are killed and the mercury is released into circulation. Therefore, as long as there continues to be an active Lyme Disease infection, it is also likely that additional mercury is sequestered throughout the body. For this reason, mercury detoxification should not be considered to be finished until all Lyme Disease bacteria are completely eradicated. A mercury removal program is often needed for quite a long time, sometimes even years.
The hair test indicates a long term mercury build up which is logical since the long exposure to Lyme in combination with mercury fillings. This immediately explains the relief of certain symptoms when taking DMPS. It limits the playground for the Lyme bacteria because one of their defenses disappear.
On the other hand, removing mercury restores immune function (which can cause higher inflammation). And I can confirm that while some symptoms have almost disappeard, some have gotten worse. Chelation is a bit like releasing the kraken, but it’s something that you have to do in order to get better. I wonder if the Elispot test would still be positive if I haven’t done chelation in the past years.
Either way, recent tests still indicate a suppressed immune system. I’ve taken high levels of zinc for several months, up to 150 mg (everything hihger than 50 mg can be toxic). During that time, my leukocytes were 5300 whereas they were 3080 previously. Leukocytes are now 4300, just within limits. (I’ve ceased all supplementation two weeks before the blood test). This was after taking 50 mg/day. This may confirm the hypothesis of Klinghardt that Lyme eliminates zinc to weaken the immune system.
I’ve increased zinc levels again to 100 mg/day.
All tests for coinfections were negative, but those tests are even less reliable than Lyme tests.
Looking at the symptoms that are related to popular coinfections, there is only one of which symptoms seem familiar. I used to have night sweats and so called ‘air hunger’ which are typical symptoms for babesia (a malaria like parasite). But they have disappeared.
Maybe those symptoms are Lyme related or maybe babesia has become dormant. Either way, it’s not really a concern at this moment.
Coinfections can greatly increase the survival rate of Lyme bacteria in the host.
The lactose and fructose tests that check for enzyme deficiencies were negative.
The bike test didn’t reveal anything special except that my maximum heart rate is 194, the maximum output was 240 Watt and the maximum capacity was reached because of respiratory muscle weakness.
When did I get infected?
The first few symptoms that are related to Lyme were massive dust mite allergies in the third grade. But that’s actually not the first sympotom. I forgot something that happened when I was young and I didn’t know that it might be related to Lyme disease. Lyme can cause a minor or severe form of ‘facial palsy’. It usually happens in children that are bitten in the neck area (because children are smaller and lower to the ground). Facial palsy is a minor paralysis of certain facial muscles causing one side of the face to be droopy. I still have a very minor form which you can see sometimes on photos. But when I was in kindergarten, I had a ‘lazy eye’ on the right side which is a droopy eyelid. I had to wear these eye patches on my left eye to train my right one. Obviously, a minor paralysis caused this.
It was around the same time that I had to wear glasses, also for my right eye.
Lyme can stay in your body without notice. It can suddenly break out or make you more sick over time. A significant amount of people don’t know when they acquired the disease.
Since antibiotics are unlikely to work at this moment, another approach is necessary to tackle the disease.
Priority number one is remodulating the immune system. Shifting the balance from Th2 to Th1 and strengthening the immune system. The inflammation in my gut produces a Th2 response.
The majority of the immune system is located in the gut. Lowering allergic reactions will free up the immune system to go after the real invadors.
By healing the gut, brain function is also improved because of the brain gut connection[/url]. If the bowel system is inflamed, the brain is aswel. Furtermore, more than 90% of all serotonin is located in the gut. It makes a lot of sense to start there.
KDM prescribed me a combination of antibiotics and probiotics.
The first antibiotics were Clindamycine (7 days) and Flagyl (5 days). Clindamycine didn’t seem to do anything.
The antibiotics must always be followed by a preriod of probiotics until the month is over. Then repeat again.
I also have to take five supplements (KDM just gives supplements without explaining why, so I had to look it up. It appears that they have a Facebook Post which explains what they want to achieve.):
Lactoferrin Complex. One of the components of the immune system of the body (mainly antibacterial, antiviral and antifungal) that is anti-inflammatory.
Choline-DHA. Enhances the connections of neurons in the brain.
Lypospheric Vitamin C. A type of vitamin C that is encapsulated in liposomes. Phospholipids should protect vitamin C from destruction by the digestive tract and allow for immediate delivery to the cells. Vitamin C increases Th1.
Hydroxycobalamin (intermuscular). Activated form of B12. This one has to be injected twice a week. Lowers nitric oxide and helps detox. Great talk about the NO/ONOO cycle here. May also remove ammonia from the brain.
Caloreen (maltodextrin). A polysaccharide that is often used as a food additive and is sometimes given to people that are malnourished. Aka, this is to gain weight.
Medicine has to be combined with a diet that is aimed at lowering allergic reactions. The main idea is to eat something different very day for four days in a row. Then start again with day one. Everything is allowed, except for the ‘extreme’ allergies (eggs in my case). All food items are kind of grouped that way to keep similar allergy types on the same day.
Flagyl caused some severe nausia for a few days and also tooth pain. But it seemed to most effective. During the whole time I took Flagyl, my stools were very dark (almost black). So I guess a lot of things were dying. I also had less pain overall (probably because Flagyl destroys cyst forms, including Lyme). KDM warned in the report that Flagyl could cause a Herxheimer reaction which happens when a bunch of toxins get released when Lyme spirochetes die. It can look like this, but it didn’t happen in my case. Herxing is not all that common.
At the end of this three month period, something strange happened. My skin became really sensitive and I had red stripes everywhere.
This is my right side:
A week later, all my joins were inflamed. Some days I couldn’t bend my knees, later I couldn’t lift my arms, then I couldn’t type or lift my backpack and sleeping was very painful. Painkillers didn’t work.
After three months, I had to come back for a reevaluation. Fortunately this was the moment when this occured (I was able to come in a few days earlier).
KDM had seen this before but never this bad. What happened was mast cell activation. Mast cells react to allergens and pathogens. Something probably changed in my bowels my immune system didn’t agree with (or some pathogen leaked from my bowels). Either way, the problem was gone after two weeks (give or take).
No new tests were performed. Everything stayed the same, except the two antibiotics were changed by another one: Normix (Rifaximin). Unfortunately this antibiotic may not be sold in Belgium (because we live in a free country), it has to be imported from Italy. This almost triples the cost of this antibiotic.
Normix is a broad spectrum antibiotic. This means that it kills everything. Gram negative bacteria have a more complex cell wall and are more antibiotic resistant. If there are too much gram negative bacteria, it takes a long time to reach a healthy balance with antibiotics and probiotics.
And two antibacterial and anti-inflammatory herbs (quercetin and curcumin) were added.
I have to take this antibiotic for about a year.
According to KDM it takes this long because all new medicine that gets developped have one or more side effects for which they do not get approved by the regulator. Wonderful right? Now all investors are hesitant to support a new product.
So far, I seem to have good results. But I have to stay on the prescribed diet. The die off that I described before only happens rarely now which is a huge improvement. I also got rid of a lot of pressure in my bowels I didn’t even know I had. I guess my gut will heal automatically if I stick with the schedule.
Until this day, my skin remains itchy combined with some minor acne. I think it is related to the antibiotics.
One setback happened. I lost quite some weight. I’m now at 61.5 kg (coming from ~67) which equates to a BMI of 17. I have to gain ~22 kg to have a normal BMI of 223. This will probably take some time.
The hydroxyB12 injections didn’t do much in the first three months but now it seems to be working for a bit more than a day.
I don’t know what the next steps will be. A lot of people seem to get good results with the Buhner protocol. (I’ve used a lot of quotes from his book in this post.) His book is really good and quite extensive. Maybe it’s a good idea to figure out the protocol and discuss it with KDM. I don’t think it will cure Lyme but it will probably change my Th2 response to Th1 and stop most of the symptoms. You can find a small oversight on his website[/url].
Personally I’m mostly concerned about long term neurological damage. The damage is similar but less severe than in multiple sclerosis. It could explain the burning and sometimes crawling feeling in my brain.
Even though most of it is reversable, this is the most scary. Either way, I’ll probably get my memory back, the dizzyness, headaches, word finding problems will hopefully disappear. Only my right eye might not cure. It is almost impossible to read anything (even with glasses) and my vision is of significantly worse quality.
My last update included complaints about ‘visual snow’ and floaters. I must have missed something back then from Wikipedia, I just noticed it now:
A condition that sometimes produces visual snow is optic neuritis (inflammation of the optic nerve). Moreover, a variety of illnesses (e.g., Lyme disease, auto-immune disease) or noxious events (dehydration) have been blamed by sufferers in self-help internet forums as causes of persisting visual snow, but none of these claims have been confirmed by scientific study. However, Lyme Disease has been shown to cause optic neuritis.
On the right side, it looks like there is some kind of static layer on top of the original picture. It’s mostly in my right eye and I don’t really notice it most of the time (because my left eye is the dominant one). It is most noticable on dark backgrounds.
The floaters are also very typical for Lyme as it is, like the central nervous system, a protective site for Lyme bacteria.
The twitching I was talking about:
It is very mild, sometimes you can feel it without being able to see it. The examples here are very short (it usually takes ~10 seconds, so it’s hard to catch it on camera). It occurs everywhere.
From the information that I can find, twitching is either a Magnesium deficiency or the Lyme bacteria have infected the central nervous system.
There is also a very slight risk of getting a heart attack (and death), because Lyme can infiltrate the heart tissue. I’m not sure if that is the case for me. I have different kind of heart related issues (palpitations – although very much less these days, stabbing and chest pain). All tests so far showed no heart block, but it’s something that I have to keep in the back of my mind.
Remember that I mentioned what I wrote in my previous update:
Turns out NAC destroys biofilms. So, it’s probably related to that.
Next post will be more about treatment once I figured out what to use.
I’m pretty sure a complete remission is possible, but it will take a few years.
Cost of the antibiotic and supplements in Euro per month (including taxes and sending):
Normix (200 mg – 3x/day): 87.80 (33.28 is the original price)
Bio-Kult (2x/day: 8.5
Hydroxycobalamin injections (10mg – 2x/week): 22
Lypospheric Vitamin C (1 mg – 3x/day): 94.02
Lactoferrin Complex (360 mg – 2x/day): 40
Choline-DHA (500 mg – 2x/day): 26
Quercumin (1000 mg – 3x/day): 58.5 (This is a combination of curcumin and quercetin.)
Total cost: about €335/month
This only includes the things prescribed and not the cost of all the other supplements.
Current supplement list:
Zinc Picolinate 100 mg
Lithium Orotate 4.6 mg (every 3 days)
Pancreatin 750 mg
L-Theanine 200 mg
Green Tea Leaf Extract 500 mg
Glycine 500 mg
Selenium 200 mcg
Alpha Lipoic Acid 150 mg
MethylB12 1 mg
Milk Thistle Extract 150 mg
Taurine 1 g
Magnesium Citrate 166 mg
Potassium Gluconate 99 mg
5-HTP 100 mg
Vitamin D3 5000 IU (every 2-3 days)
TMG 500 mg
Lecithin 1200 mg (420 mg Phosphatidylcholine) (every 4 days – on the day when I may eat soy)
B6 250 mg
Vitamin E 400 IU
Omega 3 320 mg
Copper 2.5 mg
Alpha Lipoic Acid 150 mg
Ashwaghanda 450 mg
Melatonin 1.5 mg
5-HTP 100 mg
red = remove
orange = (probably) replace
I’m back on 100 mg zinc which seems to be the tipping point. I feel better on 100 mg than on 50 mg.
I know this dose increases the chance of prostate cancer, but that’s a risk I’m willing to take.
High levels of zinc can knock off copper. That’s why included a low copper dose.
The amount of Lyme disease diagnosis made differs between countries. For example, In The Netherlands has about 129 (2009) new cases per 100000 inhabitants are recognized each year. For Sweden this is 69 (1995), for Slovenia this is 155[/url] (1997) and for Belgium this is 10 (2012).
I’m either living on sacred land, or this disease is greatly overlooked in Belgium.
This is how you loose ~20 years of your life which I’m not gonna get back.
Anyways. Persistence pays off, even when you get ignored.
At least it is something that most people kind of understand. Even though it’s a known disease, there is still a lot of misunderstanding.
I’ve read two books so far and I’ve ordered five more books about Lyme (and 1 general book about diet and auto-immune disorders which might be handy).
Storl, Wolf. Healing Lyme Disease Naturally: History, Analysis, and Treatments. North Atlantic Books, 2010.
McFadzean Ducharme, Nicola. Lyme Brain: The Impact of Lyme Disease on Your Brain, and How To Reclaim Your Smarts. BioMed Publishing Group, 2016.
Singleton, Kenneth. The Lyme Disease Solution. BookSurge Publishing, 2008.
White, Shelley. Cannabis for Lyme Disease & Related Conditions: Scientific Basis and Anecdotal Evidence for Medicinal Use. BioMed Publishing Group, 2015.
Ballantyne, Sarah. The Paleo Approach: Reverse Autoimmune Disease and Heal Your BodyCBS News . Victory Belt Publishing, 2014.
McFadzeanm, Nicola. The Lyme Diet: Nutritional Strategies for Healing from Lyme Disease. BioMed Publishing Group; Edition Unstated edition, 2010.
Buhner, Stephen. Healing Lyme: Natural Healing of Lyme Borreliosis and the Coinfections Chlamydia and Rocky Mountain Spotted Fever. Raven Press, 2015.
Horrowitz, Richard. Why Can’t I Get Better? Solving the Mystery of Lyme and Chronic Disease. St. Martin’s Press, 2013.
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