MTHFR Results Not Too Good

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This topic contains 74 replies, has 9 voices, and was last updated by  impossible 5 years ago.

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  • #114356

    impossible
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    Topics: 16
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    Im glad you’re doing better. That makes me very happy to hear.

    To give reference, thats probably about 2% of the rda of potassium. Everybody has different requirements when supplementing, but that should give you an idea.

    I want to mention something that Dr. Lynch has started preaching recently. His view is that if you get to a point where you feel awesome from taking methyl sup’s, stop taking them until you need them again. This is also important if you get to the point where you feel overdriven. If that does happen, take some time release niacin, it doesnt take much, 50-100mg a day for a few days is all it usually takes to bring a person back down.

    So you are or arent taking methyl folate & b12 yet?

    #114358

    blueocean
    Member
    Topics: 1
    Replies: 17

    Thanks, noted on the Potassium. I also eat 1 banana per day with my daily protein shake so I get some there as well. If I feel the need I’ll supplement more.

    I am not taking the methyl B12 nor the Methylfolate yet. I’m going to run this CBS sulfur protocol for 2 weeks before I start. I think the sulfur issues, like you noted are one of my biggest problems.

    One question I do have…. Should I stop the CBS protocol after the 2 weeks or should I run it simultaneously with the Methyl Cycle protocol?

    #114360

    impossible
    Member
    Topics: 16
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    Oh yea, you’re going to need to maintain it. In fact, depending on how strict you are, you might even notice some of those symptoms coming back when you start the methyls as you start to produce more homocysteine. That is why I recommended the tmg, it supports the “shortcut” pathway for turning homocysteine back into SAMe, leaving less to be converted into ammonia and sulfites. I dont remember if I mentioned it here, but turmeric also helps draw cysteine away from that pathway (in the transsulfuration pathway) and promotes its conversion into glutathione. Which is a total win. Plus you get all of its other benefits.

    #114377

    psalm34810
    Member
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    Thank you impossible and raster for your thoughts! I have a brief, updated description of my story on my blog at: http://justjuliewrites.com/about/ I’m grateful for an eBook that charts my first year of discovery with these crazy illnesses, written in a way to hopefully encourage others. Info. is available on the blog.

    My halotypes are: HLA DRBI 17-2-52B and 13-6-52B

    Below are the 23andme results:

    SNP Gene Variation Result Call

    RS4680 COMT V158M +/+ AA
    RS4633 COMT H62H +/+ TT
    RS769224 COMT 61 -/-GG
    RS731236 VDR Taq tt GG
    RS6323 MAO A R297R +/+ TT
    RS3741049 ACAT 1-02 -/-GG
    RS1801133 MTHFR C677T -/-GG
    RS2066470 MTHFR 3 -/-GG
    RS1801131 MTHFR A1298C +/-GT
    RS1805087 MTR A2756G -/-AA
    RS1801394 MTRR A66G +/-AG
    RS10380 MTRR H595Y -/-CC
    RS162036 MTRR K350A -/-AA
    RS2287780 MTRR R415T -/-CC
    RS1802059 MTRR 11 +/-AG
    RS567754 BHMT 2 -/-CC
    RS617219 BHMT 4 +/-AC
    RS651852 BHMT 8 -/-CC
    RS819147 AHCY 1 -/-TT
    RS819134 AHCY 2 -/-AA
    RS819171 AHCY 19 -/-TT
    RS234706 CBS C699T +/-AG
    RS1801181 CBS A360A +/-AG
    RS2298758 CBS N212N -/-GG
    RS1979277 SHMT C1420T -/-GG

    I’m looking into NB Wellness in Ann Arbor, MI at this time. The Candida protocol is really rough yet shows promise. Holding tough at an average of 4 hours per day total “tics of organic origin.” Yeah right. Last night: convulsions baby! Sish. Julie

    #114379

    psalm34810
    Member
    Topics: 0
    Replies: 15

    More info: I maintain the strictest of Candida & mold-free diets; my home was remediated for mold earlier this year. J

    #114398

    impossible
    Member
    Topics: 16
    Replies: 606

    Psalm, as far as your methylation status, you dont look that bad. You might want to add in some hydroxyb12, but being comt 158 and 62 +/+, you are highly likely to overmethylate incredibly easily. The comt/mao mutations help offset the mthfr 1298 mutation.

    You likely do need some treatment based on your results, just not methyl groups. You are likely to benefit from a cbs protocol, the mainstays of which are a sulfur free diet and supplementation with molybdenum and yucca root. I have yet to personally deal with someone with a 699 mutation that didnt benefit from this treatment. It is so far, by far, the most popular mutation ive seen on this forum.

    Dr Boggess is really great. How long is his waiting list right now?

    Run your detox panel and pay the $20 or whatever for the mthfrsupport panel if you can. So far you only have part of the whole story your raw data can tell.

    #114405

    psalm34810
    Member
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    Replies: 15

    Talk about being between a rock and a hard place . . .

    Re: rastor, I see that your DHA supplement is made from algae. That just won’t do for me as any mold/algae connection will be a disaster fer sure. Any other thoughts? Do lymph massage and have had cranio-sacral work that might also help CSF.

    Re: impossible, wow, some good news for once. And therein the quandary lies as with my strict Candida diet, I eat a ton of leafy green veggies, cauliflower, and so on (low carb veggies). So veggies but without fruit and grains (mold in most grains and any simple carbs trigger seizures), that only leaves chicken, limited beef, local pork, turkey, and wild caught fish. I do a lot of coconut, avocado, red palm, and olive oil (in order of descending amounts) plus limited, roasted almonds & cashews.

    The molybdenum supps I’ve found have protease in them and I have been unable to tolerate p. in any amount for years, even now with h. pylori cleared up. Guess that leaves yucca root and the cbs protocol. How do I find out about the cbs protocol?

    NB Wellness has a screening process for seeing Dr. Boggess beginning with paperwork, free 10-minute phone call with the Dr., more paperwork & a total of $125 in deposits, then they will schedule a 2-3 hour appointment. My phone call is in about 2 weeks. Thanks for the vote of confidence!

    Will look up the mthfrsupport panel. Take care all, :J

    #114410

    impossible
    Member
    Topics: 16
    Replies: 606

    Im a patient of Dr Boggess. The last I’d heard, he was scheduling 4 months out for new patients and the wait was getting longer. Im not sure he would be the best fit for you, though you should obviously leave that up to him to decide. Have you seen anybody good for the biotoxin sensitivity issue and symptoms?

    The cbs protocol is basically just eliminating foods that contain appreciable amounts of sulfur (eggs, cauliflower, broccoli, spinach, kale, etc) and adding those supplements mentioned

    #114412

    psalm34810
    Member
    Topics: 0
    Replies: 15

    Guess it’s time for a very long fast!

    My bad: unable to locate the detox panel of which you write Mr. Impossible. Where do I go? Thank you, :J

    #114414

    impossible
    Member
    Topics: 16
    Replies: 606

    https://geneticgenie.org/detox-profile/

    http://www.mthfrsupport.com/

    A true fast isnt required, just high sulfur foods, if thats what you meant. Let me know how it works out. If you are expressing the gene and its a problem, you should notice a difference in a few days.

    #114417

    Percyfaith
    Participant
    Topics: 28
    Replies: 58

    Julie, I am praying for you. I visited Hope Beyond Lyme.
    Spiritual and Physical Healing are my goals too.

    #114422

    psalm34810
    Member
    Topics: 0
    Replies: 15

    Thank you Mr. Impossible. Just not sure what I will eat as virtually any foods off of my limited diet cause seizures. Sish. Will investigate and see what I can do for a few days. Here’s the Detox Profile Results:

    Genetic Genie
    Detox Profile Results
    Gene & Variation rsID Alleles Result
    CYP1A1*2C A4889G rs1048943 TT -/-
    CYP1A1 m3 T3205C rs4986883 TT -/-
    CYP1A1 C2453A rs1799814 GG -/-
    CYP1A2 164A>C rs762551 AC +/-
    CYP1B1 L432V rs1056836 CG +/-
    CYP1B1 N453S rs1800440 TT -/-
    CYP1B1 R48G rs10012 CG +/-
    CYP2A6*2 1799T>A rs1801272 AA -/-
    CYP2A6*20 rs28399444 II -/-
    CYP2C9*2 C430T rs1799853 CC -/-
    CYP2C9*3 A1075C rs1057910 AC +/-
    CYP2C19*17 rs12248560 CC -/-
    CYP2D6 S486T rs1135840 CG +/-
    CYP2D6 100C>T rs1065852 AG +/-
    CYP2D6 2850C>T rs16947 GG -/-
    CYP2E1*1B 9896C>G rs2070676 CC -/-
    CYP2E1*1B 10023G>A rs55897648 GG -/-
    CYP2E1*4 4768G>A rs6413419 GG -/-
    CYP3A4*1B rs2740574 TT -/-
    CYP3A4*2 S222P rs55785340 AA -/-
    CYP3A4*3 M445T rs4986910 AA -/-
    CYP3A4*16 T185S rs12721627 GG -/-
    GSTP1 I105V rs1695 AA -/-
    GSTP1 A114V rs1138272 CC -/-
    SOD2 A16V rs4880 AG +/-
    NAT1 R187Q rs4986782 GG -/-
    NAT1 R64W rs1805158 CC -/-
    NAT2 I114T rs1801280 TT -/-
    NAT2 R197Q rs1799930 GG -/-
    NAT2 G286E rs1799931 GG -/-
    NAT2 R64Q rs1801279 GG -/-
    NAT2 K268R rs1208 AA -/-
    Gene Result
    GSTT1 Present

    Thank you for you willingness to help others! May the Lord bless you for your kindness. J

    #114628

    impossible
    Member
    Topics: 16
    Replies: 606

    Psalm, im still researching everything about that panel (and ive been really busy lately), give me some time and i’ll give you a good report.

    #114739

    blueocean
    Member
    Topics: 1
    Replies: 17

    Just want to update. I started my Methyl supplements today. Taking along with my cbs protocol:

    400mg MethylFolate
    200mg mB12 Sublingual
    200mg TMG
    500mg Curcumin

    As it’s day 1, not too much to report other than feeling a bit more amped up and motivated.

    #114741

    impossible
    Member
    Topics: 16
    Replies: 606

    Thats alot to start with for some. That amped up and motivated is either going to get better or get worse over the next few days/week. Keep me updated. If it gets worse and is too much, stop taking it and use 100 mg time release niacin for a few days, should bring you back down.

    Good luck!

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