Mercury exposure linked to impaired immunity to candida.

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This topic contains 1 reply, has 1 voice, and was last updated by  dvjorge 4 years, 10 months ago.

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  • #119055

    dvjorge
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    This is an old study I am aware of. I found it reviewing my archives.

    Polymorphonuclear phagocytosis and killing in workers exposed to inorganic mercury.
    Perlingeiro RC1, Queiroz ML.
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    Abstract
    The ability of neutrophils to phagocytose and kill Candida species as well as the splenic phagocytic function were investigated in workers from a mercury-producing plant. In the neutrophil phagocytosis study, two species of Candida were used since in individuals with myeloperoxidase deficiency neutrophils are unable to kill Candida albicans, while Candida pseudotropicalis can be effectively lysed. Phagocytosis of both antigens and splenic phagocytic function were normal in all the workers studied. However, following ingestion of the organisms there was considerable reduction in the ability of neutrophils from exposed workers to kill both species of Candida, and this was not explained by a mild impairment of phagocytosis. After improvement in the hygiene conditions in the factory, a new evaluation was performed, 6 months later, in the same workers and urinary mercury concentrations were determined monthly in each worker. Despite a significant reduction in urinary mercury concentrations, a greater impairment in the ability of neutrophils to kill C. albicans was observed. The killing of C. pseudotropicalis presented no further impairment when compared to the previous evaluation. These results suggest that impairment of the lytic activity of neutrophils from workers with urinary mercury concentrations within the safe level for exposed population is due, at least in part, to some interference with myeloperoxidase activity. In addition, the mercury-NADPH complex, once formed, could limit the utilization of reduced pyridine nucleotides by NADPH-dependent enzymes such as NADPH oxidase, thereby inhibiting the PMN respiratory burst.

    For those who doesn’t know it, myeloperoxidase is an enzyme that produces hypochlorite ion, which is one of the body main defenses against candida. Mercury and Lead inhibit myeloperoxidase production.

    Jorge

    #119068

    dvjorge
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    Topics: 283
    Replies: 1368

    This article is really important because it is evidence about how mercury is linked to candida infections. Hard to find information about it.

    Jorge.

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