Lead linked to impaired immunity to candida.

Home The Candida Forum Candida Questions Lead linked to impaired immunity to candida.

This topic contains 5 replies, has 3 voices, and was last updated by  lead 4 years, 10 months ago.

Viewing 6 posts - 1 through 6 (of 6 total)
  • Author
    Posts
  • #119075

    dvjorge
    Participant
    Topics: 283
    Replies: 1368

    I have seen many candida sufferers with altered lead results showed by hair mineral analysis. I mean during my years reading the forums, I have seen many DD and Genova hair analysis posted by candida sufferers showing high lead and mercury levels. Curiously, both are high many times.

    People probably think how hell they can have high lead levels if they aren’t exposure to it. However, it is a common finding.

    Lead and Mercury, both, impair the immune response against candida. Even considered “normal” levels are linked to a deficient immune response against candida. People, there is evidence. Candida sufferers should know if they are toxic or not. Without proper immunity, there isn’t hope. Diet, medicines, supplements, and nothing can eliminate a chronic fungal infection without the immune system.

    See this study:

    Engulfment and killing capabilities of neutrophils and phagocytic splenic function in persons occupationally exposed to lead
    Mary L.S. Queiroz; Fernando F. Costa; Claudia Bincoletto; Rita C.R. Perlingeiro; Denise C.M. Dantas; Mônica P. Cardoso; Mônica Almeida
    (Profiled Author: Rita Perlingeiro)
    International Journal of Immunopharmacology. 1994;16(3):239-244.

    ScopusAbstract
    Phagocytosis and intracellular killing of Candida albicans and Candida pseudotropicalis by neutrophils as well as phagocytic splenic function from lead-exposed workers were studied. Two species of Candida were used since in individuals with myeloperoxidase deficiency neutrophils are unable to kill C. albicans, whereas C. pseudotropicalis can be effectively lysed. Phagocytosis with both antigens and phagocytic splenic function were normal in all the workers studied. However, lytic activity towards C. albicans, but not C. pseudotropicalis was impaired. This defect was observed in lead-exposed workers with blood lead levels and urinary delta-aminolevuliniv acid (ALA-U) concentrations in the “safe” (below 60 ug/dl and 6 mg/l, respectively) and toxic ranges. An impaired ability to kill C. albicans suggests that lead exposure may lead to a myeloperoxidase deficiency. With the exception of blood lead levels and ALA-U concentrations, there was no correlation between any of the other parameters examined. © 1994.

    #119077

    raster
    Participant
    Topics: 104
    Replies: 6838

    What is the best chelating agent for lead?

    -raster

    #119078

    lead
    Participant
    Topics: 12
    Replies: 30

    Well, I do have CRC and I definitely have problems with lead levels in my body.

    raster: DMSA seems to be the most popular one for that. I, however, have used a different one called Penicillamine (named Cuprenil here where I live), but it seems to be problematic according to most people on the Internet and I’ve seen some studies suggesting that the DMSA does a better of job at chelating lead than Penicillamine and some others. I might put the study here. Andy Cutler agrees that DMSA is a ton better and I think he’s mentioned that Penicillamine is not a chelator at all but it does seem to have lowered my lead a bit.

    “Although d-penicillamine also shared advantage of oral administration when prescribed at 250 mg given four times for five days of therapy or 40 mg/kg/day for chronic therapy; it is no longer used for the treatment of lead intoxications as safer profile succimer is available [12].”

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922724/

    But note that the DMSA has been reported to worsen neutropenia, hence aggravating problems with CRC. I for one do have neutropenia but luckily there are ways of alleviating it. I’ve seen some studies suggesting Vitamin E does the job (http://www.ncbi.nlm.nih.gov/pubmed/19066956) and heard people claiming Arginine can do this as well (should be taken with Lysine for some reason). I’ve heard Echinacea and Ginseng help with neutropenia too.

    I’ve read a study on ncbi claiming that the green tea extract and vitamin E help out at lowering the oxidative damage done by lead.

    Note that it is very important to address oxidative stress while chelating. The article shown below claims that DMSA does not sufficiently protect against oxidative damage caused by lead.

    “Ercal et al. (10) however reported that DMSA might confer only moderate degree of protection against lead induced oxidative stress. They however, suggested possible therapeutic usefulness of NAC when administered in combination with DMSA in low-level lead exposure.”

    Some snippets from the same article above:

    “These antioxidants (vitamin C and E, α-lipoic acid etc.) when given either alone or in combination with a chelating agent proved to be effective in mobilizing metal from soft as well as hard tissue [203].”

    “Oxidative stress may be considered as one of the prime contributing mechanism in metal toxicity and thus provide a strong rationale for including antioxidants during chelation therapy (Table 2). Antioxidant supplementation with chelating agents has been found beneficial in increasing lead mobilization and providing recovery of altered biochemical variables [108,109]. Combinational therapies with antioxidants like N-acetylcysteine (NAC) [53], lipoic acid (LA) [109], melatonin [53], and gossypin [110] have shown considerable promise in improving clinical recoveries in animal models.”

    Another great article on the oxidative damage done by lead:

    http://www.cellmolbiol.com/admin/articles_generaux/OL67-Flora.pdf

    From what I’ve read it really does seem to be a great idea to use NAC together with DMSA when addressing lead toxicity.

    “However, maximal recovery was observed when NAC was concomitantly administered in combination with DMSA.”

    “Combined treatments with NAC plus DMSAand melatonin plus DMSA were slightly more effective than the effect of DMSA alone in increasing lead excretion.”

    “All the treatments, except melatonin, were able to reduce blood lead concentration significantly; the maximum depletion was observed in animals administered DMSA or DMSA plus NAC. Lead concentration in liver, kidney and brain also showed significant depletion on DMSA administration and to some extent in animals treated with NAC but the best protection was noted in animals co-administered NAC + DMSA compared to all other treatments.”

    And I’ve noticed that melatonin is a great supplement to use for alleviating oxidative damage done by lead as well:

    “Melatonin not only prevents neurotoxicity induced byKainate but also proved beneficial in preventing traumatic brain injury resulting from the generation of oxidative stress (4,25). The therapeutic efficacy of melatonin has been reported to be better than other antioxidants like glutathione and vitamin E (35,43).”

    #119079

    dvjorge
    Participant
    Topics: 283
    Replies: 1368

    lead;57599 wrote: Well, I do have CRC and I definitely have problems with the lead levels in my body, so I can possibly attest to that.

    raster: DMSA seems to be the most popular one for that. I, however, have used a different one called Penicillamine (named Cuprenil here where I live), but it seems to be problematic according to most people on the Internet and I’ve seen some studies suggesting that the DMSA does a better of job at chelating lead than Penicillamine and some others. I might put the study here.

    But note that the DMSA has been reported to worsen neutropenia, hence aggravating problems with CRC. I for one do have neutropenia but luckily there are ways of alleviating it. I’ve seen some studies suggesting Vitamin E does the job and heard people claiming Arginine can do this as well (should be taken with Lysine for some reason). I’ve heard Echinacea and Ginseng help with neutropenia too.

    Yes, DMSA is the best I know. I consider DMSA the most effective for mercury too. Better than oral DMPS, according to some authors. Neutropenia is the worse part.

    Jorge.

    #119080

    lead
    Participant
    Topics: 12
    Replies: 30

    dvjorge;57600 wrote:
    Yes, DMSA is the best I know. I consider DMSA the most effective for mercury too. Better than oral DMPS, according to some authors. Neutropenia is the worse part.

    Jorge.

    Just for a proof that DMSA does actually do a great job at chelating mercury as well:

    “Numerous animal and human studies have shown that DMSA administration increases urinary mercury excretion and reduces blood and tissue mercury concentration [42–44].”

    The quote is from this website (it contains tons of other useful information on heavy metal toxicity too):

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922724/

    #119081

    lead
    Participant
    Topics: 12
    Replies: 30

    I personally think the subforum should be for heavy metal toxicity in general, not just for mercury alone.

    Does anyone else agree? Renaming the subforum as ‘Heavy Metal Toxicity’ or something similar to that and adding this post could potentially be of great help to others imo and people with problems with mercury are quite likely poisoned with some other heavy metals as well.

    I think the subforum should just generally be about chelation and heavy metal toxicity.

Viewing 6 posts - 1 through 6 (of 6 total)

The topic ‘Lead linked to impaired immunity to candida.’ is closed to new replies.