Intersting extract on anti-fungal activity of free fatty acids

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This topic contains 2 replies, has 2 voices, and was last updated by  jameskep 6 years, 4 months ago.

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  • #91581

    jameskep
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    Extract indicates 10-undecenoic acid(sf722)as it inhibiting candida hyphal formation. Interesting how it shows certain fatty acids affecting certain strains of fungus. One thing I noticed is when i took capric acid orally it seemed to be much stronger than caprylic acid(anti-fungal activity).

    http://www.formatex.info/microbiology3/book/61-71.pdf

    #91590

    dvjorge
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    jameskep;29975 wrote: Extract indicates 10-undecenoic acid(sf722)as it inhibiting candida hyphal formation. Interesting how it shows certain fatty acids affecting certain strains of fungus. One thing I noticed is when i took capric acid orally it seemed to be much stronger than caprylic acid(anti-fungal activity).

    http://www.formatex.info/microbiology3/book/61-71.pdf

    James,
    Capric Acid is stronger than Caprylic Acid inhibiting Candida growth.

    S. Boulardii release a considerable amount of Capric Acid.

    Jorge.

    SOURCEPLoS ONE;2010, Vol. 5 Issue 8, p1
    SOURCE TYPEAcademic Journal
    DOC. TYPEArticle
    ABSTRACTCandidiasis are life-threatening systemic fungal diseases, especially of gastro intestinal track, skin and mucous membranes lining various body cavities like the nostrils, the mouth, the lips, the eyelids, the ears or the genital area. Due to increasing resistance of candidiasis to existing drugs, it is very important to look for new strategies helping the treatment of such fungal diseases. One promising strategy is the use of the probiotic microorganisms, which when administered in adequate amounts confer a health benefit. Such a probiotic microorganism is yeast Saccharomyces boulardii, a close relative of baker yeast. Saccharomyces boulardii cells and their extract affect the virulence factors of the important human fungal pathogen C. albicans, its hyphae formation, adhesion and biofilm development. Extract prepared from S. boulardii culture filtrate was fractionated and GC-MS analysis showed that the active fraction contained, apart from 2-phenylethanol, caproic, caprylic and capric acid whose presence was confirmed by ESI-MS analysis. Biological activity was tested on C. albicans using extract and pure identified compounds. Our study demonstrated that this probiotic yeast secretes into the medium active compounds reducing candidal virulence factors. The chief compound inhibiting filamentous C. albicans growth comparably to S. boulardii extract was capric acid, which is thus responsible for inhibition of hyphae formation. It also reduced candidal adhesion and biofilm formation, though three times less than the extract, which thus contains other factors suppressing C. albicans adherence. The expression profile of selected genes associated with C. albicans virulence by real-time PCR showed a reduced expression of HWP1, INO1 and CSH1 genes in C. albicans cells treated with capric acid and S. boulardii extract. Hence capric acid secreted by S. boulardii is responsible for inhibition of C. albicans filamentation and partially also adhesion and biofilm formation.

    #91620

    jameskep
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    on this website I found myristic acid which according to the document it can inhibit fungal NMT. I ordered some and going to see how it works.

    http://www.metabolics.com

    Jorge, whats interesting is that Saccharomyces boulardi secretes capric acid and capric acid is antagonistic with Saccharomyces “Cerevisiae”. Interesting how certain fatty acids affect certain strains.

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