HELP DV JORGE!!!

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This topic contains 9 replies, has 3 voices, and was last updated by  mark2 5 years, 5 months ago.

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  • #114462

    mark2
    Member
    Topics: 7
    Replies: 26

    Hi jorge ,I am on the flu……and ibu……600,ever since plus the diet and all my symtoms are acting bad and even worse ,I had to play with my body ,I tried flu… and lam…. ,itra and lamasil but as soon i as i touch the fluconazole ,this happen,last time i did this ,i had the same feeling ,but i was getting better by a little then i switch to itra….and lamasil for a month with feeling nothing, my question is after the first 15 or 30 days of ibu….pen what can i use to protect the fluconazole?Thank you and i do hope you r recovering very good.Ps symtoms r sevare burning in the urinary track ,burning in the anus etc,sevare depression etc,does this look like a die off.I really believe the fluconazole is working but want to protect it .When i was on the other antifungals i would only get nipping and pain in the urinary track .I am sure if not 99.9 people here depend on your postings.Thank u .

    mark.

    #114463

    LilDonnie
    Participant
    Topics: 3
    Replies: 15

    Hey Mark!,

    http://www.prostatitis.org/fungus.html

    I got some info from there. It suggested an internal prostate massage. I am a bit weary of the internal prostate massages I have done around 6 with varying results. The first time I had huge die off while taking Lamisil. The other times I never had such a reaction. Maybe look at some external prostate massage techniques to help loosen up some of that gunk in the prostate!

    Live Extension Lactoferrin
    N-Acetyl Cysteine NOW Brand
    Serrapeptase Solar Ray
    nattokinase Solar Ray

    I also take these to break up the biofilm of the fungus. Hope this helps. I know I am no DVJOGE but these have been my experiences 🙂

    Stay healthy my friend

    Brendon

    #114464

    dvjorge
    Participant
    Topics: 283
    Replies: 1369

    mark2;52983 wrote: Hi jorge ,I am on the flu……and ibu……600,ever since plus the diet and all my symtoms are acting bad and even worse ,I had to play with my body ,I tried flu… and lam…. ,itra and lamasil but as soon i as i touch the fluconazole ,this happen,last time i did this ,i had the same feeling ,but i was getting better by a little then i switch to itra….and lamasil for a month with feeling nothing, my question is after the first 15 or 30 days of ibu….pen what can i use to protect the fluconazole?Thank you and i do hope you r recovering very good.Ps symtoms r sevare burning in the urinary track ,burning in the anus etc,sevare depression etc,does this look like a die off.I really believe the fluconazole is working but want to protect it .When i was on the other antifungals i would only get nipping and pain in the urinary track .I am sure if not 99.9 people here depend on your postings.Thank u .

    mark.

    I can not say the organism is causing your infection is candida albicans. It has to be cultured to know. Anyway, it looks like you are dealing with an intracellular candidiasis.

    Depending of the candida species or strain, Fluconazole will be effective or not.

    There are two types of resistance, the acquired and the intrinsic. Intrinsic resistance can not be reverted combining antifungals or synergistic medicines. When a fungus is intrinsically resistant to an antifungal, you need to find an effective antifungal to treat it. Most candida species are susceptible to the azoles but some are dose dependable. What is very common is candida species acquire rapid resistance to the azoles. Ibuprofen is known to reverse this resistance and to re-activate the azole. I am not sure you can take Ibuprofen every day for long time. I am providing you information that you must consult with your Dr. It is information you can present to your Dr.

    The azoles are synergistic with several natural antifungals and prescription medicines. Most of these studies have been done “in vitro”.

    There is a very noticeable symptom increase when the intracellular candidiasis is attacked with an effective antifungal. The burning sensation increase enormously.

    You are the person who may notice if the treatment is working or not. If you take something and the yeast don’t react, that is doing nothing. However, if you take a systemic drug and you feel an intense localized reaction, such as burning, hot, intense redness, the treatment is working.

    You and your Dr have to find a combination that works.

    Here is the support for Ibuprofen. Notice it was tested “in vivo” in animal models.

    Saturday, March 31, 2012, 15:18 – 15:30
    Effective reversion of fluconazole resistance by ibuprofen in an animal model
    S. Costa-de-Oliveira*, I. M Miranda, E. Ricardo, A. Silva-Dias, A. G Rodrigues, C. Pina-Vaz (Porto, PT)
    Objectives: Ibuprofen was found to be an efficient reverter of in vitro fluconazole resistance due to overexpression of efflux pumps1,2; however its in vivo effect is still unproven.The aim of our study was to evaluate in an animal model the effect of ibuprofen associated to fluconazole in the treatment of an invasive infection by a resistant C. albicans isolate.
    Methods: A C. albicans resistant (R) strain to fluconazole was obtained by subculturing with serial concentrations of fluconazole a susceptible strain (S) during 30 days. Minimal inhibitory concentrations (MIC) to fluconazole was determined in the presence of 100µg/ml of ibuprofen (IBU), an efflux pump blocker1,2.
    Comparative transcriptome analysis between the S and the induced resistant strain (R) incubated with and without ibuprofen (RI) was performed using C. albicans DNA microarrays from Agilent Technologies.
    The in vivo study was carried out according to the murine candidiasis model. Female BALB/c mice were infected with 5×105 cells in 0.1 ml of sterile saline via the lateral tail vein with the S strain (three groups) or the R strain (three groups). Antifungal therapy was administered intraperitoneally with FLC or IBU or FLC+IBU on both groups 3 hours after microbial challenge and repeated once a day for a total of four days. The kidney fungal burden was determined.
    Results: Ibuprofen decreased azole MIC values, the R phenotype changing to S. Microarray analysis identified 836 and 1517 with differential expression in R and RI strains, respectively. The R strain showed overexpression of CDR11, ERG251, CDR4 and the transcription factor UPC2. In the RI and in the S strains those genes were down regulated.
    FLC showed to be effective only in the treatment of the infection by the S strain, reducing dramatically the fungal burden. Interestingly, in mice infected with the R strain but treated with FLC + IBU, a significant decrease in the fungal burden was observed. In the absence of FLC, IBU did not display antifungal activity per se.
    Conclusions: The in vivo synergic effect between fluconazole and ibuprofen demonstrated herein may represent a hopeful future approach for a better management of antifungal resistance conferred by efflux pump overexpression.
    1. Pina-Vaz, C., et al. J Antimicrob Chemother 2005, 4: 678-85

    Antifungal activity of ibuprofen alone and in combination with fluconazole against Candida species.
    Pina-Vaz C, Sansonetty F, Rodrigues AG, Martinez-De-Oliveira J, Fonseca AF, Mårdh PA.
    Source
    Department of Microbiology, Porto School of Medicine, University of Porto, Portugal. [email protected]
    Abstract
    Ibuprofen, a non-steroidal anti-inflammatory drug, exhibited antimicrobial activity against Candida albicans and non-albicans strains. At 10 mg/ml, ibuprofen showed a rapid cidal activity against exponential growth phase C. albicans, accompanied by rapid and extensive leakage of intracellular K+, permeation to propidium iodide, lysis of spheroplasts and severe membrane ultrastructural alterations. These results indicate that the killing of Candida cells is due to direct damage to the cytoplasmic membrane. At 5 mg/ml, ibuprofen inhibited growth; however, it did not kill the yeasts and did not directly affect the cytoplasmic membrane. Evaluation of yeast metabolic vitality with the fluorescent probe FUN-1 showed that growth inhibition induced by the fungistatic drug concentration was due to metabolic alterations. The combination of ibuprofen with fluconazole resulted in synergic activity with eight of the 12 Candida strains studied, including four of the five fluconazole-resistant strains. The MICs of fluconazole for the fluconazole-resistant strains decreased 2-128-fold when the drug was associated with ibuprofen. When in combination with fluconazole, MICs for ibuprofen decreased by up to 64-fold for all the 12 strains studied. These results point to the practicability of using ibuprofen, alone or in combination with azoles, in the treatment of candidosis, particularly when applied topically, taking advantage of the drug’s antifungal and anti-inflammatory properties.

    Ibuprofen may possess a marked therapeutic potential, particularly due to its ability to revert resistance to fluconazole. The serum
    concentration of ibuprofen needed to achieve an anti-inflammatory
    effect27 is lower than the concentration needed to obtain an antifungal effect.9
    This concentration is thus sufficient to induce the
    blockade of efflux pumps and to revert resistance to azoles. The
    anti-inflammatory and analgesic properties of ibuprofen might also
    represent an additional advantage. Additionally, our study opens
    new perspectives for treatment of candidosis by rehabilitating an
    important drug like fluconazole.
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    Jorge.

    #114465

    mark2
    Member
    Topics: 7
    Replies: 26

    Thank u jorge,Look when u say culture what u mean?urine ,i have done like about 8 ,all negative,everytime i go the r doing std and went i told them about yeast and say it will show up in the culture. One doctor give me cipro four 4 weeks,I told him u r giving me what acually brought me here,then i went back to me regular doctor ,he too is lost ,but i took your papers to him and he start to precribe the medicine,anyway thank u very much for your help.thank u all.

    #114466

    mark2
    Member
    Topics: 7
    Replies: 26

    Ps ,Jorge i know this is working ,i know my body ,thank u very much ,but what i dont know how long i can take the Ibuprofen and you r so right ,if anybody thinks fluconazole will do liver damage they r wrong only in rear cases,cause they amount of me kill medication i took would have kill a horse,all the symtoms u r saying i am having,hotness,burning,stinging,redness etc.thank u and i do hope this works.I have to solve this man,i wana see my daugher grow up ,i have been through hell for the last year and a half.thanks

    #114467

    dvjorge
    Participant
    Topics: 283
    Replies: 1369

    mark2;52986 wrote: Thank u jorge,Look when u say culture what u mean?urine ,i have done like about 8 ,all negative,everytime i go the r doing std and went i told them about yeast and say it will show up in the culture. One doctor give me cipro four 4 weeks,I told him u r giving me what acually brought me here,then i went back to me regular doctor ,he too is lost ,but i took your papers to him and he start to precribe the medicine,anyway thank u very much for your help.thank u all.

    Intracellular candidiasis doesn’t show up in urine cultures neither urethral swaps. It mus be an scrap to get a proper sample (painful) and most Drs don’t know it. Yeast are deep inside the tissues and have to be detected using microscopic technic. When an scrap is done properly, it shows yeast present. I have adviced vaginal scraps to women who has done more than 5 or 6 negative vaginal swap. The scrap has showed the fungal infection.

    I think your treatment is working since the burning increased. This happens when yeast are attacked by an effective drug.

    Jorge.

    #114468

    dvjorge
    Participant
    Topics: 283
    Replies: 1369

    mark2;52987 wrote: Ps ,Jorge i know this is working ,i know my body ,thank u very much ,but what i dont know how long i can take the Ibuprofen and you r so right ,if anybody thinks fluconazole will do liver damage they r wrong only in rear cases,cause they amount of me kill medication i took would have kill a horse,all the symtoms u r saying i am having,hotness,burning,stinging,redness etc.thank u and i do hope this works.I have to solve this man,i wana see my daugher grow up ,i have been through hell for the last year and a half.thanks

    I hope you understand I can not tell you take this and that. I am not a medical doctor. My help is providing you information you can discuss with your MD. I mean I have done many things with my body, but I am responsible of my own actions. I wish and hope you end with your nightmare. I know perfect what you are living now. It happened to me. I am giving you tools to discuss with your Dr, but it is your responsibility to consult with him and to follow him.

    Wish you Luck. Trust me, it is going to end. You are documented and know what you have.

    Jorge.

    #114470

    mark2
    Member
    Topics: 7
    Replies: 26

    Jorge,I am not crazy ,my english is not good ,i did reviews all over cure zone including remi96 ,jhan etc.nothing like your posing,i tried all 5 antifungal at once ,and the yeast party,i tried itra ,lamasil,nystatin,candex, ,.I mean at once.This syndrome mess up my very high paying job and all the doctor thinks i need mental help,i recently did a normal colonoscopy with a gi doctor which is normal,when i tell him about my issue,I had an argrument with him and left.You and i know the pain ,its not easy ,day and night.I did not know nothing about this and i think my md is gona fix me .Now he is being honest and said he just dont know.One uro convince me its a nerve issue ,and i waited till i notice my penis start glands start to hang infront and i started to see red and black rash on the glands of the penis,then i know this is candida ,then i took the flu…..and ibu…. but only for six weeks and i know the hanging went away but the infection did not and it came back,another thing this thing feeds on raw salads.So anybody watching and think a diet will cure u ,think again.Thank u very much jorge,i am trying to get this under controll so i can start the heavy metal detox,oh boy i really get caught up in a situation.

    mark.

    #114471

    dvjorge
    Participant
    Topics: 283
    Replies: 1369

    mark2;52991 wrote: Jorge,I am not crazy ,my english is not good ,i did reviews all over cure zone including remi96 ,jhan etc.nothing like your posing,i tried all 5 antifungal at once ,and the yeast party,i tried itra ,lamasil,nystatin,candex, ,.I mean at once.This syndrome mess up my very high paying job and all the doctor thinks i need mental help,i recently did a normal colonoscopy with a gi doctor which is normal,when i tell him about my issue,I had an argrument with him and left.You and i know the pain ,its not easy ,day and night.I did not know nothing about this and i think my md is gona fix me .Now he is being honest and said he just dont know.One uro convince me its a nerve issue ,and i waited till i notice my penis start glands start to hang infront and i started to see red and black rash on the glands of the penis,then i know this is candida ,then i took the flu…..and ibu…. but only for six weeks and i know the hanging went away but the infection did not and it came back,another thing this thing feeds on raw salads.So anybody watching and think a diet will cure u ,think again.Thank u very much jorge,i am trying to get this under controll so i can start the heavy metal detox,oh boy i really get caught up in a situation.

    mark.

    I have not doubt about what you say. I know your symptoms and the red form of candida. What I am telling you is I can not order you a treatment. I help you providing you information you may discuss with your Dr. You are a lucky one who knows what you have. There are people living with chronic prostatitis for years without knowing it may be fungal. There are women with vulvodynia for many years, suffering, depressed, and ruined when a proper antifungal treatment may resolve it. Most of the medical community aren’t aware of this situation.

    Good Luck,

    Jorge.

    #114473

    mark2
    Member
    Topics: 7
    Replies: 26

    jorge Thank u very much.Thank u .

    mark.

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