Yes it can help. Ann Boroch in her book how to get rid of Candida in 90 days talks about that antifungal. Here is quote from book:
Diflucan (to jump-start only; then switch to Nystatin)
As I explained in Chapter 3, pharmaceutical antifungals (Diflucan and Nystatin) are recommended for autoimmune and cancer conditions or if you have severe anxiety and/or depression or mental illness. Diflucan can be taken to give your body a jump-start and kill off systemic fungus at the beginning of your program. After jump-starting with Diflucan, as described below, you can then switch to Nystatin or an herbal antifungal.