Crohn's disease associated to fungus

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  • #113176

    dvjorge
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    Topics: 283
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    Hi all,

    This is the first medical proof yeast are present on the inflamed intestinal tissues that cause Crohn’s disease.

    This article give you an idea how implicated are fungus in all IBD cases.

    Dysbiosis of Gut Fungal Microbiota is Associated With Mucosal Inflammation in Crohn’s Disease
    Li, Qiurong MD, PhD; Wang, Chenyang MS; Tang, Chun MS; He, Qin MS; Li, Ning MD; Li, Jieshou MD
    Open Access
    Supplemental Author MaterialPublished Ahead-of-Print
    Collapse BoxAbstract
    Goals: We aim to characterize the fungal microbiota in the intestinal mucosa and feces in patients with Crohn’s disease (CD).

    Background: Fungi represent a diverse microbial community in the human intestine and might play a role in the pathogenesis of CD; however, little is known about the structure and composition of the fungal microbiota especially adhering to the intestinal mucosa in CD patient.

    Study: Nineteen patients with active CD and 7 healthy individuals were recruited in this study. The mucosa-associated and fecal fungal microbiotas in CD patients were analyzed using culture-independent community fingerprint techniques.

    Results: The fungal richness and diversity were significantly elevated in the inflamed mucosa compared with the noninflamed mucosa. The predominant fungal composition in the inflamed mucosa was strikingly altered, mainly characterized by expansion in the proportions of Candida spp., Gibberella moniliformis, Alternaria brassicicola, and Cryptococcus neoformans. The fecal fungal community was perturbed in CD patients as accompanied by increased fungal diversity and prevalence in Candida albicans, Aspergillus clavatus, and C. neoformans. The species richness and diversity of the mucosal fungal community were associated with the expression of TNF-[alpha], IFN-[gamma], or IL-10 (P<0.05). The diversity of the fecal fungal microbiota positively correlated with serum C-reactive protein and CD activity index (P<0.05).

    Conclusions: This study first demonstrates that the fungal microbiota in the inflamed mucosa is distinguishable from that of the noninflamed area. Shifts of gut fungal microbiota composition may be associated with mucosal inflammation and disease activity of CD. Our data would provide novel insights into understanding the potential of gut fungal microbiota in the pathogenesis of CD.

    This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

    (C) 2013

    #113590

    klips32
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    Topics: 65
    Replies: 183

    very good find Jorge, thanks

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