Chloroquine (the malaria drug) a cure?!

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  • #73116

    Ibiza-Rio
    Member
    Topics: 5
    Replies: 12

    Can anyone with a medical background please translate this study:

    http://m.jac.oxfordjournals.org/content/55/2/223.full

    A few sentences have given me hope:

    ” It can be assumed that liposome-mediated delivery of chloroquine to macrophages results in an unfavourable (alkaline) environment for the growth of C. neoformans inside macrophages”

    “Thus, the use of chloroquine for prevention and treatment of fungal infections could result in improved outcome by decreasing morbidity from both the fungal as well as HIV infection.”

    “”Moreover, the antifungal activity of fluconazole increases when used in combination with liposomal chloroquine”

    The study is aimed at the effect on C. neoformans and not Candida Albicans but a google Search reveals that they are both fungi so hopefully results are similar??

    I have been fatigued and sleeping non stop for the last 4 days and thought it may have been a side effect of the malaria pills I was taking. However fatigue is not a common side effect, especially to the degree that I have been getting it, which lead me to think that maybe the chloroquine and candida may be contraindicated. Instead I stumbled upon this study which could in fact suggest the contrary! I am now crossing my fingers and toes that my fatigue is simply die off as the last of my candida is brutally slaughtered by the chloroquine!!!

    Thoughts anyone?!?

    #73128

    Able900
    Spectator
    Topics: 92
    Replies: 4811

    “Moreover, the antifungal activity of fluconazole increases when used in combination with liposomal chloroquine”

    With this information, one would assume that if fluconazole is the antifungal being used against Candida albicans, and adding liposomal chloroquine results in an increased potency of fluconazole against the C. albicans, then what you’re suggesting seems more than just plausible.

    The study is aimed at the effect on C. neoformans and not Candida Albicans but a google Search reveals that they are both fungi so hopefully results are similar??

    Since they’re both a fungi, it makes sense that it would work at least to some degree against C. albicans as well.

    I have been fatigued and sleeping non stop for the last 4 days and thought it may have been a side effect of the malaria pills I was taking.

    Sounds exactly like die-off. Without finding a study showing that liposomal chloroquine is also effective against C. albicans fungi, one can only assume that it is from the apparent positive effects it presents (if one can call die-off symptoms positive).

    Able

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