Cell wall deficient microbes and bacteria

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    When you take antibiotics, it strips the cell walls from a variety of beneficial bacteria and microbes in your body. When this occurs, your body cannot recognize these cell wall deficient bacteria which then causes a variety of immune problems in the long term.

    “Some publications have suggested that L-form bacteria might cause diseases in humans, and other animals but, as the evidence that links these organisms to disease is fragmentary and frequently contradictory, this hypothesis remains controversial. The two extreme viewpoints on this question are that L-form bacteria are either laboratory curiosities of no clinical significance or important but unappreciated causes of disease. Research on L-form bacteria is continuing. For example, L-form organisms have been observed in mouse lungs after experimental inoculation with Nocardia caviae, and a recent study suggested that these organisms may infect immunosuppressed patients having undergone bone marrow transplants. The formation of strains of bacteria lacking cell walls has also been proposed to be important in the acquisition of bacterial antibiotic resistance.

    L-form bacteria may be useful in research on early forms of life, and in biotechnology. These strains are being examined for possible uses in biotechnology as host strains for recombinant protein expression. Here, the absence of a cell wall can allow production of large amounts of secreted proteins that would otherwise accumulate in the periplasmic space of bacteria. The accumulation of proteins in the periplasmic space can be toxic to the bacteria, which may reduce the yield of the expressed proteins.”


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