- March 18, 2013 at 1:35 am #100942
dvjorgeParticipantTopics: 283Replies: 1368
Candida Albicans is not only able to neutralize Th1 but also Th17 by a different mechanism.
Recent studies have found it:
V. Inhibition of IL-17 production
394 IL-17 has been suggested to be an important component of host defense against Candida
395 infection (22,45). Candida cell wall components, especially mannans and β-glucans, are
396 recognized by CLRs such as MR, dectin-1, and dectin-2, leading to inflammasome activation,
397 IL-1β production, and subsequent induction of IL-17 (106,110). Recently, it was
398 demonstrated that C. albicans could actively inhibit host IL-17 production by altering host
399 tryptophan metabolism. Tryptophan metabolism is regulated by two distinct enzymes:
400 Indoleamine 2,3-dioxygenase (IDO) and tryptophan hydroxylase. By inhibiting IDO
401 expression, C. albicans could shift tryptophan metabolism and this leads to less kynurenines
402 and more 5-hydroxytrptophan metabolites. The increased 5-hydroxytryptophan subsequently
403 inhibits host IL-17 production (20).
The same candida is in charge of neutralizing the immune response we need to eliminate it.
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