23andme results – Homozygous MTHFR A1298C & R297R. Please advise!

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    Hi, I recently received my 23andme results. I have included the homozygous/ heterozygous mutations. I have been spending a lot of time on educating myself. It’s a lot of information & starts getting quite complex. I would welcome any advice/tips to work my way around them & better my life. Thanks, John.

    Methylation Profile –

    Homozygous –

    MAOA R297R rs6323 T +/+
    MTHFR A1298C rs1801131 GG +/+

    Heterozygous –

    COMT V158M rs4680 AG +/-
    COMT H62H rs4633 CT +/-
    VDR Bsm rs1544410 CT +/-
    VDR Taq rs731236 AG +/-
    MTRR H595Y rs10380 CT +/-
    MTRR K350A rs162036 AG +/-
    MTRR A664A rs1802059 AG +/-
    CBS A360A rs1801181 AG +/-
    SHMT1 C1420T rs1979277 AG +/-

    Detox Profile –

    Homozygous –

    CYP2D6 S486T rs1135840 GG +/+
    CYP2D6 100C>T rs1065852 AA +/+
    NAT2 R197Q rs1799930 AA +/+

    Heterozygous –

    CYP1A1*2C A4889G rs1048943 CT +/-
    CYP1B1 L432V rs1056836CG +/-
    CYP1B1 N453S rs1800440 CT +/-
    CYP2C9*3 A1075C rs1057910 AC +/-
    CYP2C19*17 rs12248560 CT +/-

    Gene Result
    GSTT1 Present


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    The two members who were really knowledgeable on methylation here, Impossible and Tdogg33 (or something similar, not sure of the number of gs and 3s there), might not be around much anymore (nor am I for that matter.)
    I’ve seen them both at phoenix rising but not recently.
    Your best bet for getting a really good interpretation of this is there, at PR.
    You and I share some snps.

    I can’t even begin to offer you meaningful interpretation. I would recommend reading through Amy Yasko’s huge website, focusing particularly on her advice on first priority snps (and keeping in mind that her CBS advice has been challenged and your CBS snps are at the lowest end of severity). She considers SHMT to be first priority to treat also, before starting methylation.

    CHeck out heartfixer.com too and just keep reading through his stuff. It’s taken me many weeks and a lot of fog blowing away before I could begin to grasp parts of this cycle and information. Also, Sarah Myhill has a lot on her website, though it may overlap with Dr. Roberts’ stuff.

    Just at a glance, MAOA is significant, MTHFR 1298 homozygous is going to mean a need for folate (whether that is folinic acid or methylfolate, I can’t say) MTRRs will indicate a higher need for methylb12s. I’d really start by reading at PR. Find Caledonia and read the link in her sig. They’re full of incredible information.

    Good luck!

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