Reply To: the link between mercury and immunosuppression?

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ThomasJoel2
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klips32;52112 wrote: http://pac.iupac.org/publications/pac/pdf/2009/pdf/8101×0153.pdf

I’m still searching for the precise link between high mercury levels in body and immunosuppression/alteration(autoimmune etc.) toward getting more susceptible to fungi/yeast infections/allergic reaction vs. same.

From the above article: ” The changes in cytokine production reflect changes in T-cell populations, and mercury(II) chloride has been proposed to cause immune dysfunction by favoring activation of TH2 cells over TH1 lymphocytes [36]. Some of these immunostimulatory effects are related to autoimmune effects.”

Test on mice with TH2 dominant response and a TH1 dominant response vs. c. albicans has shown that the TH1 dominant had no problems getting rid of the yeast compared to TH2 dominant. This is nothing new in our world, just wanted to clarify. Will see if I can find the exact study again.

Can anyone say anything more on this topic? More studies? What I have here is not conclusive.

I won’t give you a link to a scientific study, but some information that may help guide you in order to find what you’re looking for.

From what I understand, mercury is one of the big factors that can disrupt the methylation cycle. Once the methylation cycle is not functioning properly a whole host of things go wrong. Amy Yasko writes the following in her Pathways book:

Methylation also plays a key role in the ability of our immune system to recognize foreign bodies or antigens to which it needs to respond. Whenever there is an assault on the immune system, the body must synthesize new T cells, which belong to your white blood cells. These cells help fight viral and parasitic infections, and are also needed to help to control B cells, which produce antibodies. Due to mutations in the methylation pathway, you may lack the ability to produce the methyl groups necessary for making new cells. When that occurs, there is an increased tendency to produce B cells, which may therefore result in an autoimmune disorder. When I and my practitioner colleagues look at the blood work of many of the children, we often find these kinds of imbalances–they have too many auto-antibodies, not enough of a T-cell response, and too much of a B-cell response. I have seen several cases in which the level of auto-antibodies has declined after proper methylation cycle supplementation.

Methylation of DNA also regulates immune cells. Immune receptor DNA is initially in the “off” state and remains that way until the immune cells need to differentiate in order to respond to an intruder. As you will learn in greater detail below, at that time the DNA loses its methyl groups in a regulated fashion and the DNA is turned “on.”

As we have just seen, methylation is generally correlated with the silencing of genes. But research has also shown that when genes are not methylated at specific points, the immune system can be tricked into reacting against itself.

So, to sum up, methyl groups help turn your genes on and off. They also help determine the ways your immune system reacts. Unless methylation is operative, the immune system may react when it’s not needed, creating autoimmune disorders, or fail to respond to actual threats when it is needed.