home › The Candida Forum › Candida Questions › Sugar binge after 1 week on diet, antifungals & probiotics. Sugar addicted noob only making it worse › Reply To: Sugar binge after 1 week on diet, antifungals & probiotics. Sugar addicted noob only making it worse
impossible;51830 wrote: Im still 100% sold on the cell-mediated tolerance idea, in all but the most severe of cases anyway. Il-10 mimicking/overproduction & IFN esp g blockers/antagonists can put a SERIOUS dent in cellular immunity. Enough to cause huge suppresion of Th1 cell production and even a total loss of oral tolerance. Combine that with altered antigen presentation due to downregulated dendritic cell production, a proliferation of Th2 presenting innate cells due to a long term prescence of Th2 cytokines, mhc class 2 downregulation and (big one) intracellular glutathione depletion and then an altered redox state and what comes with that, I can definately see how a person would not produce a weal.
Have there been any studies done that cultured cells from a “tolerant” person, tested them particularly in the absence of Th2 cytokine/ cytokine producing cells and presented them with antigen then measured cytokine production and cytotoxic cd8 activity? Or any broad studies done for other co-infections? Or a measure of dendritic cell counts?
There are studies demonstrating how mucosal infections with candida albicans affect cell-mediated immunity and the suppressors cells. It is well known by medicine candida albicans has mechanisms to maneuver the immune response that attacks it. It looks like one time the infection sets, there is a huge influence by it on the necessary immune response to clear it.