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Able900;36837 wrote:

Pharmaceutical grade probiotics DON’T attach the intestinal lining permanently. There isn’t prove of it. They do temporary colonization until you be supplementing them.

I posted the information below in June of 2012 in response to a similar statement from Dvjorge.

A percentage of beneficial bacteria from oral probiotics do colonize in the intestines. The fact that it’s an unknown percentage which depends on other factors is why we suggest such high amounts of CFUs to be taken throughout the treatment.

The research below was reported in the Applied and Environmental Microbiology journal in April 2010 as well as the Therapeutic Advances in Gastroenterology journal in May 2011.

A study was conducted on human subjects to test the colonization ability of oral probiotics containing strains of lactobacillus given as probiotic supplements to a group of volunteers; the volunteers were given a total of two doses a day for 17 days at which point the lactobacillus probiotic was stopped. The volunteers then went through an 18-day washout period in an attempt to clear the intestines completely of beneficial bacteria. During this time, feces of the volunteers were tested for strains of the bacteria. The samples were taken at days 0 and 18 during the oral dose period as well as during and following the washout period; there were a total of 12 volunteers. The highest number of volunteers who continued to host the specific lactobacillus bacteria strains was 10 out of 12, and other samples showed the lowest number hosting the same species of lactobacillus to be 7 out of 12 samples.

According to the report, the experiment revealed that (and this is a quote) “Beneficial bacteria of the lactobacillus species obtained by human beings via the oral administration are capable of colonization in the human intestines.”

I have repeated this a million of times but they DON’T last more than 3 months. I have been in contact with the Gordon Lab that is working in the Genome Proyect. I have discussed it with people who has been investigating it for years. If I go to the Curezone archives where I have posted more than 2000 times, I can find long discussions about it with people who have dedicated years to battle candida. There is reliable scientific information in the web from medical sources that recognize that permanent colonization hasn’t been proved. I have dedicated a huge amount of hours to find medical papers demonstrating possible pharmaceutical probiotic colonization that be permanent, but it isn’t demonstrated. They colonize but they don’t last. After 18 days of stopping supplementation they can be detectable, even after 60 days, but not after 90 days. I don’t post garbage. Go to the Probiotic Organization and read about it.

It looks like my bad English isn’t well understood. They DO colonize but only temporary. There aren’t proves they do colonize permanently. It is a matter of time ( months at best ) that they aren’t detectable in feces or biopsies. People need to know that. People need to know that the benefits are as long as you supplement them. You gonna find articles about L. Reuteri, V-299, and other species that have been detectable after 60 days of stopping them, but no longer than 3 months. They decline very fast until there isn’t more detection.

An article claiming they can detect them after 18 days don’t say me anything since I have read other papers detecting colonization after 60 days. What is important is they do form colonies and growth in the intestines. This is something that has to be seen in the future with pharmaceutical grade probiotic, if it is ever possible.


This is fragment of a Patent Production from one of the larger Pharmaceutical grade Probiotic in the world. It is 2012 patent. I am posting it, but I won’t continue arguing about it or any other topic. That time already passed for me. It is your turn to find the true and the best way to recover your health. It has been hard for me and I am doing an effort to help. That is it.

[0004] The gastrointestinal microflora has been shown to play a number of vital roles in maintaining gastrointestinal tract function and overall physiological health. For example, the growth and metabolism of the many individual bacterial species inhabiting the gastrointestinal tract depend primarily upon the substrates available to them, most of which are derived from the diet. See e.g., Gibson G. R. et al., 1995. Gastroenterology 106: 975-982; Christi, S. U. et al., 1992. Gut 33: 1234-1238. These finding have led to attempts to modify the structure and metabolic activities of the community through diet, primarily with probiotics which are live microbial food supplements. The best known probiotics are the lactic acid-producing bacteria (i.e., Lactobacilli) and Bifidobacteria, which are widely utilized in yogurts and other dairy products. These probiotic organisms are non-pathogenic and non-toxigenic, retain viability during storage, and survive passage through the stomach and small intestine. Since probiotics do not permanently colonize the host, they need to be ingested regularly for any health promoting properties to persist. Commercial probiotic preparations are generally comprised of mixtures of Lactobacilli and Bifidobacteria, although yeast such as Saccharomyces have also been utilized.

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