I start and stop my S. Boulardii. My ND says this is fine and to listen to what my body’s needs are. This is especially true when facing strong die-off.
Major die-off symptoms can last anywhere from a few days to a few months. I have had die-off to some extent off and on for about 14 weeks now. Certainly it is not as severe as when I started, but I am still not well and when I take my S. Boulardii I can still often feel a fluey-type feeling. Some forum members who have been around for a long time report getting die-off even up to a year after starting the protocol. These forum members also report a lot of positive signs though and I am sure they will be along to shortly to give you wiser answers than I.