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The main “end product” of the methionine cycle is SAMe, which then runs around methylating things, including DNA, which effectively turns it off. Thats one reason a slowed methyl cycle is a big deal, otherwise you might uncap that cancer gene, or whatever. That article is saying flouride blocks SAMe from methylating those particular genes.
The list of ways anybody with bad intentions can screw up the health of the populace is quite long actually. This subject has held my interest for a while. The best way to screw with the methyl cycle would be with metals or any toxic substance that would tie up any specific enzyme in the cycle. We are being exposed to massive amounts of both of these. Anything that creates large amounts of inflammation, such as a viral or spirochete infection, can hurt it too. I dont totally discount, at all, that we are seeing exposure to all of those in that regard.
I think the scariest part of gmo food is that it actually changes YOUR dna. The body has ways of dealing with this, but they were meant to deal with it in levels that humans faced in a clean non toxic non gmo world.