Reply To: Methylation Results Are Back!

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Good stuff! Im gonna have to delve deeper into the krebs cycle and pick up a biochem textbook.

I wonder if nicotinamide would have the same effects on COMT as niacinamide. Since tryptophan is rx only (thank the release of prozac and our wonderful FDA for that one,it was originally banned entirely even) I wonder if using 5htp, with any other possible cofactors if needed, would cut it.

Lipo ATP seems like it would be expensive, probably prohibitively. Im not sure about the stuff in that link you provided. I always search pr on stuff like that, I wonder how effective a good sup would be in a case like yours. Methylation issues, especially in the case of gd-pmb, can indirectly affect some of those. Another thing to keep in mind when you are dealing with cfs is hypoperfusion. I really think that is a one of the few major factors involved, I think most things are an effect of it.

“CCSVI (Chronic Cerebral Spinal Venous insufficiency) — seen in 100% of Cheney’s CFS patients tested (n=20 to date). Back-and-forth flow reversal of the deep cerebral spinal veins. That’s going to destroy capillary function in the central nervous system.

CHVI (Chronic Hepatic Venous Insufficiency) — seen in 100% of Cheney’s CFS patients tested (n=20 to date). Capillary flow reversal in the liver.

This is a complication of right ventricular squeeze compensation for diastolic dysfunction. It is probably the most serious complication that I’ve ever found in CFS. It will destroy effective capillary function in the brain and in the liver.

Results are catastrophic, because if you don’t have proper capillary flow in the brain, you neither deliver sufficient oxygen and nutrients to the brain nor do you remove toxins from the brain.

Likewise in the liver, you just knock out important liver function, ranging from detoxification, which will put you at risk for food sensitivities and drug sensitivities. You will create xenobiotic toxicity of all kinds of things. Worst of all, it’s your center of gravity for redox control. The primary center of gravity for redox control, especially NADPH production, is in the liver, and that’s going to be impaired.

CCSVI: A doppler ultrasound technique used on cerebral venous outflow tracts in the neck and in deep cerebral vessels developed by Dr. Paola Zamboni in Italy in 2008. First characterized in MS patients by Dr. Zamboni; later discovered in autism and chronic Lyme disease; currently observed in 100% of CFS cases to date; somewhat controversial in respect to invasive vascular interventions even though such interventions have helped some but not all patients with CCSVI.

CHVI: A doppler ultrasound technique used on hepatic venous outflow tracts in the liver first described by Dr. Cheney (“I know no one else who has even looked for this”). First characterized in CFS patients by Dr. Cheney; also seen in what some have called chronic lyme; currently observed in 100% of CFS cases to date; associated with CCSVI in 100% of CFS cases to date; findings of CHVI confirmed by two ultrasound certified radiologists in California and Italy; linked to the physiology of pure diastolic dysfunction.

Because of the big artery squeeze, you get a very high tricuspid regurgitant flow that’s passing from the right ventricle through the tricuspid valve going in the opposite direction of venous return. This pressure pulse (which is almost 30 ml of mercury, which is pretty high) going in the opposite direction leads to a return blood flow that’s actually low, because there is a low (aortic?) output. Therefore with the low return pressures, meeting a high pressure pulse going in the opposite direction, you have the potential to reverse the flow of blood. That’s what you see in some of the pictures — that red splash is a flow reversal in the hepatic vein.
It’s supposed to be blue, with blood moving toward the heart. When it’s red, the blood is moving from the heart up toward the liver. Reversal is never normal, and unbelievably that’s what I see in 100% of my patients.

The cause of it is that big RV cavitation to compensate for diastolic dysfunction. And enough that the venous return is actually low.
With a low return coming back and a big powerful squeeze pushing blood the other way. That will knock out effective liver capillary function and a lot of problems will ensue.

This is our first attempt to treat this. We’re using Vasoactive Intestinal Peptide (VIP). This was developed by Dr. Ritchie Shoemaker who recently published a paper on the use of nasal VIP. This is the TRmaxPG pre-VIP treatment and then 5 minutes post. What we saw was a derogation of the TRmaxPG, which is the pressure pulse causing reversal flow. That dropped by 8, 22 and 38% respectively in three consecutive patients.

If you can drop out this pressure pulse, you can actually stop refluxing in the liver. Because what VIP does is it’s a potent nasal dilator. So a squirt up your nose will cause the cardiovasculator to dilate, which means that when the right ventricle squeezes, blood goes out the pulmonary artery rather than back through the tricuspid valve. You’re reducing the pressure so it moves in the right direction and much less of it goes in the wrong direction, causing these big drop-offs in the TRmaxPG.

See this big red blotch here? That’s flow reversal. If you watched it in real time, it would be blue-red, blue-red, blue-red. Five minutes after nasal VIP treatment, we completely abolished it. No more blue-red, blue-red. Just blue, blue, blue. Very odd, very impressive and very encouraging, because to date no one has had any idea how one might actually reverse CCSVI or CHVI. This could have tremendous clinical impacts on these patients.

* 28 Amino Acid Peptide
* Member of the Glucagon/Secretin Superfamily
* Similar to Growth Hormone Releasing Hormone
* Produced in the gut, pancreas and hypothalmus
* VIP receptors (GPCR) found in CNV, liver, lung, intestine, T-lymphocyte, heart, adipose tissue, kidney, skeletal muscle, testis, stomach
* Responsible for circadian rhythm
* Increases intestinal motility, pancreatic secretion, biliary secretion (this may be one of the reasons we see reduced biliary secretion ejection fractions in the gall bladder in almost every patient), stomach pepsin secretion, inhibits stomach Hcl, increases chronotropism and inotropism in the heart (Rx chronic heart failure?)
* Potent pulmonary vasodilator (Rx PAH – FDA approved for that)

If you dilate the pulmonovascular bed, you promote forward flow and stop flow reversal, which is what we think the primary mechanism is. Certainly that explains why it does it so quickly.

This is Dr. Shoemaker’s paper, which is going to be an important one. He just published it this week actually, using nasal VIP on 20 patients who had what he calls Chronic Inflammatory Response Syndrome related to Water Damaged Buildings, because he’s a mold expert.

By the way, there is no clinical difference between CIRS due to water damaged buildings and Chronic Fatigue Syndrome. We trade patients. I get his patients that he can’t seem to fix with mold, and he gets my patients that I can’t seem to fix because maybe they have mold. So we keep trading patients, and we can’t tell the difference between them.

This 18 month therapy with nasal VIP corrected numerous inflammatory biomarkers (C4a, TGF-beta 1, VEGF, MMP9); corrected numerous hormones (estrogen-M, testosterone-M, D3); reduced pulmonary artery systolic pressure; increased T-reg cell levels (CD4+ CD25+’s), which means it tends to reduce some of the pro-inflammatory effects of the disease; and enhanced quality of life in 100% of cases.

No doubt: if you can reverse flow reversal into the brain and the liver, you will get better.

This is what we think the mechanism is. Due to the low cardiac output, we see a big right ventricular squeeze. If you squeeze really really hard, this little tricuspid valve held by very weak capillary muscles will give way. And when it gives way, a jet of blood from this squeezing right ventricle will shoot into the right atrium or shoot right up into the superior vena cava. And if the return is low, you will see flow reversal.

In the case of the inferior vena cava, you see blood moving down into the liver and cause flow reversal with every beat.

We have observed a respiratory component so that when they inhale, you get a greater return and you don’t see the flow reversal stop, because there’s not blood coming back in to be reversed. On the exhalation, there’s a much lower return, and that’s when you see the red flash.

Requirements for Reflux:
1. Low cardiac output to produce low venous return.
2. Excess RV ejection fraction percentage to produce high TR
3. All caused by diastolic dysfunction.

All diastolic dysfunction is caused by energy impairment, caused by redox impairment. And we do not know what causes redox impairment.”

You should get Dr Conleys book America Exhausted.
You’ll find this interesting

I want to add for the readers that many other infections like lyme or co-infections are often misdiagnosed as cfs and treatment of that will usually result in those patients getting better. Lyme infections can also induce a physiological state of CFS as well.

I still think there is some ghost factor involved too, some mystery bug or biotoxin or something that is causing an extended inflammatory response in alot of people.