Reply To: Methylation Results Are Back!

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Tdog333
Member
Topics: 25
Replies: 245

Yeah it will all be a lot easier with more energy and no fog for sure.

I’m starting creatine today, gonna load up and see if it helps or not.

http://www.ncbi.nlm.nih.gov/pubmed/23869894

http://www.ncbi.nlm.nih.gov/m/pubmed/12701824/

People with a GAMT mutation might want to look into supplementing with creatine, my GAMT was normal, but I’m still hoping it will help some.

I can’t remember if I said this but I dropped the ADB down to 1MG and upped the hydroxy to one full lozenge(2MG), I’m thinking of either going up to 3MG or just staying at this dose and starting some methylfolate/folinic acid.

I’m looking into more depth on some of the homozygous mutations that seem pretty important.

TCN2 C766G : Apparently this one is involved in transport of b12, so I think if I understand it right, I need extra large doses of b12(also due to the MTR and MTRR), but at the same time I can overmethylate easily due to COMT — I’m gonna look into this one more but it seems important.

IGF1R summary :

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The
insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor
generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an
anti-apoptotic agent by enhancing cell survival. (provided by RefSeq, Jul 2008)
=

FCGR2A

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune
response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as
macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct 2008)

NOS2 Not really sure yet

I think these were the most interesting ones I found in the MTHFR panel report