Reply To: Methylation Results??

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I’ll try to write more tomorrow, just wanted to give you a brief summary.

Overall- not too bad. The MTHFR is the biggest concern.

Your COMT and VDR mutations should balance each other pretty well so that’s good.

You are hetero for both the A1298C and C677T MTHFR so methylfolate will be very important, avoid Folic Acid.

MTRR is responsible for regenerating B12, even though you are only hetero you can bypass it by taking methylb12.

BHMT 08 is the “short cut” for turning homocysteine into methionine. You can take Phosphatidylserine, phosphatidylcholine, and betaine hcl or TMG to help boost this pathway.

CBS (you are +/+ homozygous) converts Homocysteine into Cystathione
You may find it very helpful to avoid any sulfur containing foods. It really depends on the individual though. Some people with CBS mutations don’t have reactions to sulfur containing foods, and some have very bad reactions. There is new research showing CBS isn’t really a factor once you get your methylation working properly.
Here’s what heartfixer says about CBS:

Up to 10-fold up regulation, generating sulfur breakdown products, depleting glutathione, and generating Ammonia, leading to “brain fog” and stressing the Urea cycle such that BH4 levels fall, leading to a decrease in serotonin and dopamine production. Sulfur activates the stress/cortisol/adrenaline response, creating chronic “fight or flight”. G6PDH may be affected, leading to abnormalities in sugar control. Excess Alpha-Keto-Glutarate can lead to excitotoxin activity, especially if Aluminum and Mercury are present. Methylation intermediates will “fall through this drain”, so the entire system suffers; our defense against viral invasion and toxicity suffers. Co-Q10 and Carnitine generation will fall off due to impaired Methylation, and ATP levels fall, and in this case, more Alpha-Keto-Glutarate will be generated and converted into hydrogen sulfide, also contributing to “brain fog”. The Ammonia detoxifying Urea cycle is strained, more BH4 is used up to neutralize ammonia. Without adequate BH4 NOS (Nitric Oxide Synthase) generates Superoxide instead of Nitric Oxide, compromising cardiovascular function.  Betaine-Homocysteine Methyltransferase

If you do find benefit from cutting out sulfur you can try using sulfate skin patches and see how you feel with them because sulphate is pretty important.

Overall your results look pretty decent comparatively, just supplement with the right stuff and you will be good to go.

Supplements to look into:
Enzymatic Therapy Methylb12
Solgar Methylfolate(metafolin)
Jarrow Carnitall
Anabol Naturals ADB12

There are a few others, but those 4 should really get you going