Reply To: Lead linked to impaired immunity to candida.

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lead
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Well, I do have CRC and I definitely have problems with lead levels in my body.

raster: DMSA seems to be the most popular one for that. I, however, have used a different one called Penicillamine (named Cuprenil here where I live), but it seems to be problematic according to most people on the Internet and I’ve seen some studies suggesting that the DMSA does a better of job at chelating lead than Penicillamine and some others. I might put the study here. Andy Cutler agrees that DMSA is a ton better and I think he’s mentioned that Penicillamine is not a chelator at all but it does seem to have lowered my lead a bit.

“Although d-penicillamine also shared advantage of oral administration when prescribed at 250 mg given four times for five days of therapy or 40 mg/kg/day for chronic therapy; it is no longer used for the treatment of lead intoxications as safer profile succimer is available [12].”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922724/

But note that the DMSA has been reported to worsen neutropenia, hence aggravating problems with CRC. I for one do have neutropenia but luckily there are ways of alleviating it. I’ve seen some studies suggesting Vitamin E does the job (http://www.ncbi.nlm.nih.gov/pubmed/19066956) and heard people claiming Arginine can do this as well (should be taken with Lysine for some reason). I’ve heard Echinacea and Ginseng help with neutropenia too.

I’ve read a study on ncbi claiming that the green tea extract and vitamin E help out at lowering the oxidative damage done by lead.

Note that it is very important to address oxidative stress while chelating. The article shown below claims that DMSA does not sufficiently protect against oxidative damage caused by lead.

“Ercal et al. (10) however reported that DMSA might confer only moderate degree of protection against lead induced oxidative stress. They however, suggested possible therapeutic usefulness of NAC when administered in combination with DMSA in low-level lead exposure.”

Some snippets from the same article above:

“These antioxidants (vitamin C and E, α-lipoic acid etc.) when given either alone or in combination with a chelating agent proved to be effective in mobilizing metal from soft as well as hard tissue [203].”

“Oxidative stress may be considered as one of the prime contributing mechanism in metal toxicity and thus provide a strong rationale for including antioxidants during chelation therapy (Table 2). Antioxidant supplementation with chelating agents has been found beneficial in increasing lead mobilization and providing recovery of altered biochemical variables [108,109]. Combinational therapies with antioxidants like N-acetylcysteine (NAC) [53], lipoic acid (LA) [109], melatonin [53], and gossypin [110] have shown considerable promise in improving clinical recoveries in animal models.”

Another great article on the oxidative damage done by lead:

http://www.cellmolbiol.com/admin/articles_generaux/OL67-Flora.pdf

From what I’ve read it really does seem to be a great idea to use NAC together with DMSA when addressing lead toxicity.

“However, maximal recovery was observed when NAC was concomitantly administered in combination with DMSA.”

“Combined treatments with NAC plus DMSAand melatonin plus DMSA were slightly more effective than the effect of DMSA alone in increasing lead excretion.”

“All the treatments, except melatonin, were able to reduce blood lead concentration significantly; the maximum depletion was observed in animals administered DMSA or DMSA plus NAC. Lead concentration in liver, kidney and brain also showed significant depletion on DMSA administration and to some extent in animals treated with NAC but the best protection was noted in animals co-administered NAC + DMSA compared to all other treatments.”

And I’ve noticed that melatonin is a great supplement to use for alleviating oxidative damage done by lead as well:

“Melatonin not only prevents neurotoxicity induced byKainate but also proved beneficial in preventing traumatic brain injury resulting from the generation of oxidative stress (4,25). The therapeutic efficacy of melatonin has been reported to be better than other antioxidants like glutathione and vitamin E (35,43).”