From Dr. Lynch, for both of you-
One has to keep in mind that methylation is dynamic and one can shift quickly from under and overmethylated – in a matter of an hr it is possible – or less – especially if utilizing potent nutrients such as methylfolate or methylcobalamin.
We have to keep in mind that there may be other mutations on board – such as COMT. Niacin speeds up COMT which is one reason why it also may be useful. If one speeds up COMT, then things like dopamine and epinephrine get broken down faster. Niacin also is a ‘sponge’ for methyl groups, namely SAMe, because SAMe is required to metabolize niacin.