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It is very well possible to target the colon with medication that is taken orally.
Such medication is called the retard form of the medicine. Here, retard is the technical term for ‘delayed’.
It means that the pills have a special coating that dissolves slowly, but only in an environment with the right pH (acidity). So you ingest a pill, and the coating will remain around the pill inside the stomach, because the stomach is so acid. Then the pill, still surrounded by its coating, enters the colon. From then on, the coating will dissolve – but only very, very slowly.
By selecting the right coating, such retard pills can be made to deliver their contents at any place in the colon.