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Toxicologic reactions and food poisoning. Foods may contain toxins that are naturally part of the food or that were added by mistake during manufacturing, shipping, or handling. For instance, some types of fish (especially tuna and mackerel) contain histadine that is converted to histamine with improper storage, which can cause an adverse reaction if the fish is stored and/or prepared improperly. Food poisoning results from contamination with bacteria or other microorganisms. Symptoms of food poisoning and histamine toxicity may closely resemble symptoms of allergic reactions.