My experience is that people say they get die-off almost right away, though in my case it took about 1 – 1 1/5 months before I felt anything. Then it hit me full force. It started one night early summer a couple of months ago. I had been taking a spoonful of coconut oil and a few drops Oil of Oregano. I got a very unpleasant pain in my stomach. And every time since then I get die-off consisting of pain, diarrhea, nausea, sometimes vomiting and the flu-like feeling, sometimes even suicidal thoughts (don’t know if anyone else experience a bad reaction on the psyche, but I do, it sounds harsh I know, but somehow you’ll get through it). But lately it has actually been much better! Hoping it will continue this way.