Reply To: Cimetidine (Tagamet) Restoring Cell-mediated immunity

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More information about Cimetidine

A study from 2005 suggests cimetidine helps increase specific types of T-lymphocytes with protective attributes in the peripheral blood. Six healthy adults were given an 800-mg oral dose of cimetidine daily, and blood samples were collected at the study’s onset and one, three, five, and seven days later. Cimetidine treatment was associated with an increase in white blood cells, specifically neutrophils (cells that fight bacterial invaders) and T-lymphocytes (which are involved in cell-mediated immunity). These results further suggest that cimetidine modulates cellular immunity and may be useful as an activator of tumor-specific immune response.22

In sum, cimetidine appears to support cellular immunity via several mechanisms, including blocking the immunosuppressive effect of histamine, inhibiting suppressor T-cell activity, increasing the number of tumor-infiltrating lymphocytes, and boosting the activity of peripheral blood lymphocytes.