Reply To: Chloroquine is the cure. Medical study against similar fungus correlates

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slate01
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I also found a study which I think fits in with the study that you posted and may indicate that Candida is equally susceptible to chloroquine. This study shows that Candida hyphae do indeed infect macrophages, preventing them from completing cell division and therefore producing any daughter cells. However, the researchers do state that some of these macrophages can then produce large multinuclear macrophages which may or may not be helpful in eliminating Candida. This part is a little confusing.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430961/

Another interesting point in the study you posted is that they mention that the fungus Histoplasma capsulatum is also inhibited by chloroquine by impeding the acquisition of iron. From what I’ve read Candida is rather dependent on iron, so it may be this mechanism at play when you take the chloroquine.

So it seems it is possible that if the chloroquine is absorbed by the macrophages and prevents them from being properly infected by Candida, as it does with H capsulatum and C neoformans, then it is likely that the candida would be not only be killed within the macrophage but also a greater number of macrophages would be able to be produced through cell division (as macrophage cell division/multiplication is no longer impeded). This may mean even more macrophages available to destroy the Candida and a faster rate of recovery. This is just my hypothesis of course.